PMID- 23246931
OWN - NLM
STAT- MEDLINE
DCOM- 20130703
LR  - 20171116
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 75
DP  - 2013 Mar 5
TI  - A microflow chemiluminescence sensor for indirect determination of dibutyl 
      phthalate by hydrolyzing based on biological recognition materials.
PG  - 123-9
LID - S0731-7085(12)00615-2 [pii]
LID - 10.1016/j.jpba.2012.11.010 [doi]
AB  - A microflow chemiluminescence (CL) sensor for determination of dibutyl phthalate 
      (DBP) based on magnetic molecularly imprinted polymer (MMIP) as recognition 
      element was fabricated. Briefly, a hydrophilic molecularly imprinted polymer 
      layer was produced at the surface of Fe(3)O(4)@SiO(2) magnetic nanoparticles (MNPs) via 
      combination of molecular imprinting and reversible stimuli responsive hydrogel. 
      In this protocol, the initial step involved co-precipitation of Fe(2)(+) and Fe(3)(+) in 
      an ammonia solution. Silica was then coated on the Fe(3)O(4) nanoparticles using a 
      sol-gel method to obtain silica shell magnetic nanoparticles. The MMIP was 
      synthesized using methacrylic acid (MAA) as functional monomer and ethylene 
      glycol dimethacrylate (EGDMA) as cross-linker and 2,2-azobisisobutyronitrile 
      (AIBN) as initiator in chloroform. Then the synthesized MMIP and magnetic 
      non-molecular imprinted polymers (MNIP) were employed as recognition by packing 
      into lab-made straight shape tubes, connected in CL analyzer for establishing the 
      novel sensor with a single channel syringe pump. And a mixer for hydrolyzing of 
      DBP was followed. Based on this experiment principle, DBP was determined 
      indirectly. And the MMIP showed satisfactory recognition capacity to DBP, 
      resulting to the wide linear range of 3.84 x 10(-)(8) to 2.08 x 10(-)(5) M and the low 
      detection limit of 2.09 x 10(-)(9) M (3sigma) for DBP. The relative standard deviation 
      (RSD) for DBP (3.20 x 10(-)(6) M) was 1.40% (n=11). Besides improving sensitivity and 
      selectivity, the sensor was reusable. The proposed DBP-MMIP-CL sensor has been 
      successfully applied to determine DBP in drink samples.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Qiu, Huamin
AU  - Qiu H
AD  - School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, 
      China.
FAU - Fan, Lulu
AU  - Fan L
FAU - Li, Xiangjun
AU  - Li X
FAU - Li, Leilei
AU  - Li L
FAU - Sun, Min
AU  - Sun M
FAU - Luo, Chuannan
AU  - Luo C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121126
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Carcinogens, Environmental)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Plasticizers)
RN  - 0 (Polymers)
RN  - 2286E5R2KE (Dibutyl Phthalate)
RN  - 25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Beverages/analysis
MH  - Biosensing Techniques
MH  - Carcinogens, Environmental/*analysis/chemistry
MH  - Dibutyl Phthalate/*analysis/chemistry
MH  - Food Contamination
MH  - Fruit/chemistry
MH  - Hydrogel, Polyethylene Glycol Dimethacrylate/chemistry
MH  - Hydrolysis
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Limit of Detection
MH  - Luminescent Measurements
MH  - Magnetite Nanoparticles/chemistry
MH  - Materials Testing
MH  - Molecular Imprinting
MH  - Plasticizers/*analysis/chemistry
MH  - Polymers/chemistry
MH  - Reproducibility of Results
MH  - Rheology/instrumentation
MH  - Silicon Dioxide/chemistry
MH  - Surface Properties
EDAT- 2012/12/19 06:00
MHDA- 2013/07/05 06:00
CRDT- 2012/12/19 06:00
PHST- 2012/09/29 00:00 [received]
PHST- 2012/11/07 00:00 [revised]
PHST- 2012/11/07 00:00 [accepted]
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/07/05 06:00 [medline]
AID - S0731-7085(12)00615-2 [pii]
AID - 10.1016/j.jpba.2012.11.010 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2013 Mar 5;75:123-9. doi: 10.1016/j.jpba.2012.11.010. Epub 
      2012 Nov 26.