PMID- 23247064
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20211021
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1495
DP  - 2013 Feb 7
TI  - The BDNF val(66)met polymorphism is not related to motor function or short-term 
      cortical plasticity in elderly subjects.
PG  - 1-10
LID - S0006-8993(12)01850-1 [pii]
LID - 10.1016/j.brainres.2012.12.004 [doi]
AB  - The brain derived neurotrophic factor (BDNF) val(66)met polymorphism affects 
      function of the motor system in young subjects, but little is known about motor 
      system effects in the elderly. The current study assessed motor system physiology 
      and behavior, plus a measure of short-term motor cortex plasticity using 
      transcranial magnetic stimulation, in 38 elderly subjects, then examined whether 
      findings varied in relation to BDNF genotype. Baseline data were also collected 
      from 14 young subjects. At baseline, elderly subjects had poorer motor 
      performances, larger motor cortex maps, and smaller motor evoked potentials 
      compared to young subjects. Degree of age-related differences in neurophysiology 
      correlated inversely with motor performance, for example, larger map area 
      correlated with weaker pinch grip force (r=-0.42, P=0.01). In elderly subjects, 
      baseline behavior and neurophysiology did not differ in relation to BDNF 
      genotype. In addition, although map area increased significantly (P=0.03) across 
      30 min of exercise, this change did not vary according to BDNF genotype. Aging is 
      associated with changes in neurophysiology that might represent a compensatory 
      response. The data do not support an association between BDNF genotype and 
      behavior, neurophysiology, or short-term cortical plasticity in the motor system 
      of healthy elderly subjects.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - McHughen, Stephanie A
AU  - McHughen SA
AD  - Departments of Anatomy and Neurobiology, University of California, Irvine, CA, 
      USA.
FAU - Cramer, Steven C
AU  - Cramer SC
LA  - eng
GR  - P50 AG016573/AG/NIA NIH HHS/United States
GR  - P50AG16573/AG/NIA NIH HHS/United States
GR  - 5M011RR-00827-29/RR/NCRR NIH HHS/United States
GR  - R01 NS058755/NS/NINDS NIH HHS/United States
GR  - M01 RR000827/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20121213
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Aging/*physiology
MH  - Brain Mapping
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Motor Activity/*genetics
MH  - Motor Cortex/physiology
MH  - Neuronal Plasticity/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcranial Magnetic Stimulation
MH  - Young Adult
PMC - PMC3552061
MID - NIHMS429114
EDAT- 2012/12/19 06:00
MHDA- 2013/07/23 06:00
PMCR- 2014/02/07
CRDT- 2012/12/19 06:00
PHST- 2012/06/18 00:00 [received]
PHST- 2012/12/03 00:00 [revised]
PHST- 2012/12/04 00:00 [accepted]
PHST- 2012/12/19 06:00 [entrez]
PHST- 2012/12/19 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
PHST- 2014/02/07 00:00 [pmc-release]
AID - S0006-8993(12)01850-1 [pii]
AID - 10.1016/j.brainres.2012.12.004 [doi]
PST - ppublish
SO  - Brain Res. 2013 Feb 7;1495:1-10. doi: 10.1016/j.brainres.2012.12.004. Epub 2012 
      Dec 13.