PMID- 23249970
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20151119
IS  - 1536-0237 (Electronic)
IS  - 0883-5993 (Linking)
VI  - 28
IP  - 1
DP  - 2013 Jan
TI  - Late gadolinium enhancement in cardiac sarcoidosis: characteristic magnetic 
      resonance findings and relationship with left ventricular function.
PG  - 60-6
LID - 10.1097/RTI.0b013e3182761830 [doi]
AB  - PURPOSE: Cardiac involvement is an important prognostic factor in sarcoidosis, 
      and cardiovascular magnetic resonance (CMR) imaging with late gadolinium 
      enhancement (LGE) can facilitate the identification of cardiac sarcoidosis (CS). 
      In patients with CS, we investigated LGE characteristics and their relationship 
      with left ventricular (LV) function to identify those characteristics unique to 
      severely reduced LV function. We also investigated the relationship between LGE 
      and duration of sarcoidosis. MATERIALS AND METHODS: We retrospectively evaluated 
      19 patients with CS diagnosed according to the 2006 revised guidelines of the 
      Japanese Ministry of Health and Welfare who underwent CMR imaging. We analyzed 
      LGE location using 17-segment and subsegment (subepicardial, midwall, 
      subendocardial, and transmural) models and evaluated the relationship between the 
      characteristics of LGE and LV ejection fraction (LVEF) and duration of 
      sarcoidosis. RESULTS: Images of 17 of the 19 patients showed LGE most frequently 
      in the subepicardial layer. The total number of affected segments with LGE 
      correlated significantly with LVEF (r=-0.84, P<0.0001) and LV-diastolic volumes 
      (r=0.88, P<0.0001). Transmural lesions were significantly more common in patients 
      with LVEF of 35% or lower than in those with LVEF exceeding 35% (P=0.0004). All 
      patients with LVEF of 35% or lower had both subepicardial and transmural lesions. 
      The total number of affected segments with LGE correlated with the duration of 
      sarcoidosis in patients with onset in an extracardiac organ (r=0.76, P=0.005). 
      CONCLUSIONS: Demonstration of a characteristic LGE pattern and location allows 
      diagnosis of CS, and CMR imaging with LGE aids in prediction of LV function.
FAU - Watanabe, Eri
AU  - Watanabe E
AD  - Department of Cardiology, Institute of Geriatrics, Tokyo Women's Medical 
      University, 2-15-1 Shibuya, Shibuya-ku, Tokyo 150-0002, Japan. 
      ewatanab@bc4.so-net.ne.jp
FAU - Kimura, Fumiko
AU  - Kimura F
FAU - Nakajima, Takatomo
AU  - Nakajima T
FAU - Hiroe, Michiaki
AU  - Hiroe M
FAU - Kasai, Yufuko
AU  - Kasai Y
FAU - Nagata, Makoto
AU  - Nagata M
FAU - Kawana, Masatoshi
AU  - Kawana M
FAU - Hagiwara, Nobuhisa
AU  - Hagiwara N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Thorac Imaging
JT  - Journal of thoracic imaging
JID - 8606160
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Cardiomyopathies/complications/*diagnosis/physiopathology
MH  - *Contrast Media
MH  - Female
MH  - *Gadolinium
MH  - Humans
MH  - Image Enhancement/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sarcoidosis/complications/*diagnosis/physiopathology
MH  - Ventricular Dysfunction, Left/complications/diagnosis/*physiopathology
EDAT- 2012/12/20 06:00
MHDA- 2013/07/10 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - 00005382-201301000-00009 [pii]
AID - 10.1097/RTI.0b013e3182761830 [doi]
PST - ppublish
SO  - J Thorac Imaging. 2013 Jan;28(1):60-6. doi: 10.1097/RTI.0b013e3182761830.