PMID- 23250003
OWN - NLM
STAT- MEDLINE
DCOM- 20130920
LR  - 20180816
IS  - 1473-5873 (Electronic)
IS  - 0955-8829 (Linking)
VI  - 23
IP  - 1
DP  - 2013 Feb
TI  - No support for a role for BDNF gene polymorphisms rs11030101 and rs61888800 in 
      major depressive disorder or antidepressant response in patients of Finnish 
      origin.
PG  - 33-5
LID - 10.1097/YPG.0b013e3283586308 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is suggested to play a role in the 
      aetiology of major depression and in the antidepressant response in patients with 
      major depression. Several BDNF gene polymorphisms have been investigated in the 
      above-mentioned context. The aim of the present study was to examine the role of 
      two BDNF gene polymorphisms (rs11030101 and rs61888800) in relation to the 
      response to selective serotonin reuptake inhibitor medication in 106 patients of 
      Finnish origin suffering from major depression. The secondary objective was to 
      evaluate the association of these two BDNF polymorphisms in major depression, as 
      we also had a control population of 386 healthy individuals. We did not find any 
      significant differences in the distribution of these two BDNF gene polymorphisms 
      in our patient population in relation to remission or response to treatment with 
      selective serotonin reuptake inhibitor. Also, there were no significant 
      differences between the patients and the controls.
FAU - Illi, Ari
AU  - Illi A
AD  - Medical School, University of Tampere, Tampere, Finland.
FAU - Viikki, Merja
AU  - Viikki M
FAU - Poutanen, Outi
AU  - Poutanen O
FAU - Setala-Soikkeli, Eija
AU  - Setala-Soikkeli E
FAU - Nuolivirta, Timo
AU  - Nuolivirta T
FAU - Kampman, Olli
AU  - Kampman O
FAU - Leinonen, Esa
AU  - Leinonen E
FAU - Huhtala, Heini
AU  - Huhtala H
FAU - Mononen, Nina
AU  - Mononen N
FAU - Lehtimaki, Terho
AU  - Lehtimaki T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Psychiatr Genet
JT  - Psychiatric genetics
JID - 9106748
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Demography
MH  - Depressive Disorder, Major/*drug therapy/*genetics
MH  - Female
MH  - Finland
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
EDAT- 2012/12/20 06:00
MHDA- 2013/09/21 06:00
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
AID - 00041444-201302000-00005 [pii]
AID - 10.1097/YPG.0b013e3283586308 [doi]
PST - ppublish
SO  - Psychiatr Genet. 2013 Feb;23(1):33-5. doi: 10.1097/YPG.0b013e3283586308.