PMID- 23250006
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20220321
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 2
IP  - 12
DP  - 2012 Dec 18
TI  - Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and 
      aversive emotional learning.
PG  - e205
LID - 10.1038/tp.2012.128 [doi]
AB  - The medial prefrontal cortex (mPFC) is known to regulate executive decisions and 
      the expression of emotional memories. More specifically, the prelimbic cortex 
      (PL) of the mPFC is implicated in driving emotional responses via downstream 
      targets including the nucleus accumbens and amygdala, but mechanisms are yet to 
      be fully understood. Therefore, we investigated whether prelimbic cortical 
      brain-derived neurotrophic factor (BDNF) signaling through the high-affinity 
      tyrosine kinase receptor B (TrkB) receptor may serve as a molecular mechanism 
      underlying emotional memory encoding. Here, we utilized viral-mediated inducible 
      bdnf deletion within the PL, as well as TrkB(F616A) mutant mice, wherein TrkB 
      receptor point mutation results in its being highly sensitive to inhibition by 
      small PP1-derivative molecules, serving as a specific TrkB inhibitor. The 
      site-specific TrkB antagonism and viral-mediated bdnf deletion within the PL 
      resulted in deficits in both cocaine-dependent associative learning and fear 
      expression. Deficiencies were rescued by the novel TrkB agonist 
      7,8-dihydroxyflavone, indicating that PL BDNF expression and downstream signaling 
      through the TrkB receptor are required for memory formation in both appetitive 
      and aversive domains.
FAU - Choi, D C
AU  - Choi DC
AD  - Center for Behavioral Neuroscience, Department of Psychiatry and Behavioral 
      Sciences, Emory University, Atlanta, GA 30329, USA.
FAU - Gourley, S L
AU  - Gourley SL
FAU - Ressler, K J
AU  - Ressler KJ
LA  - eng
GR  - F32 MH085443/MH/NIMH NIH HHS/United States
GR  - P51 RR000165/RR/NCRR NIH HHS/United States
GR  - F32MH085443/MH/NIMH NIH HHS/United States
GR  - R01DA01962/DA/NIDA NIH HHS/United States
GR  - P51RR000165/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20121218
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
RN  - 0 (6,7-dihydroxyflavone)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavones)
RN  - 0 (Membrane Glycoproteins)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Appetitive Behavior/drug effects/physiology
MH  - Association Learning/drug effects/*physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Conditioning, Classical/drug effects/physiology
MH  - Flavones/pharmacology
MH  - Membrane Glycoproteins/drug effects/genetics/*metabolism
MH  - Memory/*physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Mutant Strains
MH  - Prefrontal Cortex/*metabolism
MH  - Protein-Tyrosine Kinases/drug effects/genetics/*metabolism
MH  - Signal Transduction/drug effects/physiology
PMC - PMC3565191
EDAT- 2012/12/20 06:00
MHDA- 2013/06/01 06:00
PMCR- 2012/12/01
CRDT- 2012/12/20 06:00
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - tp2012128 [pii]
AID - 10.1038/tp.2012.128 [doi]
PST - epublish
SO  - Transl Psychiatry. 2012 Dec 18;2(12):e205. doi: 10.1038/tp.2012.128.