PMID- 23251287
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 5
IP  - 1
DP  - 2013 Jan
TI  - Analysis of the expression of KIR and HLA-Cw in a Northeast Han population.
PG  - 300-304
AB  - The aim of this study was to investigate the expression of the human leukocyte 
      antigen (HLA)-Cw and killer cell immunoglobulin-like receptor (KIR) genes in a 
      Jilin Han population and to provide a theoretical basis for further studies of 
      their roles in disease. A total of 154 unpaid Jilin Han blood donors were 
      selected and KIR and HLA-Cw genotyping was performed using PCR-SSP. Recognition 
      of HLA-Cw and the corresponding activatory or inhibitory KIR receptor was 
      distinguished according to the identification of HLA-Cw and KIR. In the present 
      study, the expression frequency of HLA-C2(Lys80)+2DL1 was 27.27%, 
      HLA-C1(Asn80)+2DL2/2DL3 was 68.83%, 2DS2+HLA-C1(Asn80) was 9.74% and 
      2DS1+HLA-C2(Lys80) was 9.74%. Of the individuals in the study, 72.08% expressed 
      only KIR2DL1 without HLA-Cw, 21.43% expressed only KIR2DS1 without 
      HLA-Cw(Lys)-KIR2DL1 and 2.60% expressed only KIR2DS2 without 
      HLA-Cw(Asn)-KIR2DL2/L3. In conclusion, the expression of inhibitory HLA-Cw-KIR is 
      higher than the expression of activating HLA-Cw-KIR and approximately 20% of the 
      individuals separately expressed the activated HLA-Cw-KIR in the Jilin Han 
      population in the present study.
FAU - Han, Yu
AU  - Han Y
AD  - Jilin Blood Center, Changchun, Jilin 130033;
FAU - Zhao, Ling
AU  - Zhao L
FAU - Jiang, Zhenyu
AU  - Jiang Z
FAU - Ma, Ning
AU  - Ma N
LA  - eng
PT  - Journal Article
DEP - 20121025
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC3524289
EDAT- 2012/12/20 06:00
MHDA- 2012/12/20 06:01
PMCR- 2012/10/25
CRDT- 2012/12/20 06:00
PHST- 2012/06/03 00:00 [received]
PHST- 2012/10/08 00:00 [accepted]
PHST- 2012/12/20 06:00 [entrez]
PHST- 2012/12/20 06:00 [pubmed]
PHST- 2012/12/20 06:01 [medline]
PHST- 2012/10/25 00:00 [pmc-release]
AID - etm-05-01-0300 [pii]
AID - 10.3892/etm.2012.763 [doi]
PST - ppublish
SO  - Exp Ther Med. 2013 Jan;5(1):300-304. doi: 10.3892/etm.2012.763. Epub 2012 Oct 25.