PMID- 23252911
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20221207
IS  - 1651-2227 (Electronic)
IS  - 0803-5253 (Linking)
VI  - 102
IP  - 4
DP  - 2013 Apr
TI  - The lactase persistence -13910C>T polymorphism shows indication of association 
      with abdominal obesity among Portuguese children.
PG  - e153-7
LID - 10.1111/apa.12134 [doi]
AB  - AIM: The -13910C>T single nucleotide polymorphism located upstream of the lactase 
      gene (LCT) was found tightly associated with lactase persistence in European 
      populations. Recently, it was also associated with body mass index (BMI) and 
      obesity in European adults. The aim of this study was to test the association of 
      -13910C>T polymorphism with obesity-related traits and risk of obesity in 
      children. METHODS: We genotyped 580 Portuguese children (6-12-year-olds) for the 
      -13910C>T polymorphism using TaqMan probes by real-time PCR. Anthropometric 
      measurements were assessed in all children. Obesity was defined according to the 
      International Obesity Task Force (IOTF) cut-offs and abdominal obesity using the 
      sex and age-specific >/=90th waist circumference percentile. RESULTS: We found 
      indication for an association between the-13910*T allele and children abdominal 
      obesity (odds ratio [OR] = 1.41; 95% confidence intervals [CI]: 1.03-1.94; p = 
      0.030). Under the dominant model, the indicative association was observed between 
      the LCT-13910 CT/TT genotypes and abdominal obesity, remaining significant after 
      adjustment for age and gender (OR = 1.65; 95% CI: 1.04-2.60; p = 0.029). No 
      association was detected with the risk of obesity (p = 0.350). CONCLUSION: Our 
      results suggest that the -13910C>T polymorphism may predispose to abdominal 
      obesity in Portuguese children. The association with BMI or risk of obesity, 
      previously observed in adults, was not confirmed.
CI  - (c)2012 The Author(s)/Acta Paediatrica (c)2012 Foundation Acta Paediatrica.
FAU - Albuquerque, David
AU  - Albuquerque D
AD  - Department of Life Sciences, Research Centre for Anthropology and Health (CIAS), 
      University of Coimbra, Coimbra, Portugal.
FAU - Nobrega, Clevio
AU  - Nobrega C
FAU - Manco, Licinio
AU  - Manco L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130109
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - EC 3.2.1.108 (Lactase)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Child
MH  - Female
MH  - Humans
MH  - Lactase/*genetics
MH  - Lactose Intolerance/*genetics
MH  - Male
MH  - Obesity, Abdominal/*genetics
MH  - Polymorphism, Genetic
MH  - Portugal
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Waist Circumference/genetics
MH  - White People/*genetics
OTO - NOTNLM
OT  - Abdominal Obesity
OT  - BMI
OT  - LCT -13910C>T polymorphism
OT  - Portuguese children
OT  - Waist circumference
EDAT- 2012/12/21 06:00
MHDA- 2013/10/29 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/09/03 00:00 [received]
PHST- 2012/11/14 00:00 [revised]
PHST- 2012/12/12 00:00 [accepted]
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
AID - 10.1111/apa.12134 [doi]
PST - ppublish
SO  - Acta Paediatr. 2013 Apr;102(4):e153-7. doi: 10.1111/apa.12134. Epub 2013 Jan 9.