PMID- 23253237
OWN - NLM
STAT- MEDLINE
DCOM- 20130529
LR  - 20151119
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 15
IP  - 6
DP  - 2012 Dec
TI  - Associations of HLA-DRB1 alleles with anti-citrullinated protein 
      antibody-positive and anti-citrullinated protein antibody-negative rheumatoid 
      arthritis in northern east part of Turkey.
PG  - 538-45
LID - 10.1111/j.1756-185X.2011.01604.x [doi]
AB  - AIM: The aim of this study was to investigate the associations between human 
      leukocyte antigen (HLA)-DRB1 alleles with genetic susceptibility to rheumatoid 
      arthritis (RA) and production of antibodies against cyclic citrullinated peptide 
      (anti-CCP antibody) and rheumatoid factor (RF) in Turkish RA patients. METHODS: 
      We studied 291 RA patients and 253 controls. Genotyping was performed by 
      polymerase chain reaction with sequence-specific oligonucleotide probes 
      hybridization method. Serum levels of anti-CCP antibody, IgM-RF and high 
      sensitive C-reactive protein titers were measured by commercial kits using 
      immunological methods. RESULTS: We found that HLA-DRB1*04 and *09 alleles were 
      associated in anti-CCP+ and anti-CCP+ RA patients (P < 0.0001 and P < 0.001, 
      respectively), while DRB1*01 and *04 were determined to be higher in RF+ RA 
      patients (P < 0.001 and P < 0.0001, respectively). Moreover, DRB1*11 and DRB1*13 
      alleles were determined to be lower in RF and anti-CCP/RF+ RA patients (P < 0.001 
      for both). HLA-DRB1*04 was identified as a common responsible allele for 
      susceptibility to the disease in anti-CCP, RF and anti-CCP/RF- RA patients (P = 
      0.0018, P = 0.0004 and P = 0.0023, respectively). HLA-DRB1*13 allele alone was 
      found to be protective against to anti-CCP+ and RF- RA (P = 0.0003 and P = 0.006, 
      respectively). On the contrary, there was no protective allele in anti-CCP/RF- RA 
      as well as anti-CCP- RA patients. CONCLUSION: This study indicates that associate 
      and protective HLA-DRB1 allele distributions are different in autoantibody 
      (anti-CCP or RF or anti-CCP/RF)+ RA and autoantibody- RA patients, with 
      exceptions of DRB1*04 and DRB1*13.
CI  - (c) 2012 The Authors. International Journal of Rheumatic Diseases (c) 2012 Asia 
      Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty 
      Ltd.
FAU - Ucar, Fahri
AU  - Ucar F
AD  - Departments of Medical Biology & Genetics, Karadeniz Technical University, 
      Trabzon, Turkey. fahriucar61@yahoo.com
FAU - Capkin, Erhan
AU  - Capkin E
FAU - Karkucak, Murat
AU  - Karkucak M
FAU - Yucel, Burcu
AU  - Yucel B
FAU - Sonmez, Mehmet
AU  - Sonmez M
FAU - Alver, Ahmet
AU  - Alver A
FAU - Kaklikkaya, Nese
AU  - Kaklikkaya N
FAU - Tosun, Mehmet
AU  - Tosun M
FAU - Alemdaroglu, Emel
AU  - Alemdaroglu E
FAU - Solak, Mustafa
AU  - Solak M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110304
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Peptides, Cyclic)
RN  - 0 (cyclic citrullinated peptide)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/blood/epidemiology/*genetics/immunology
MH  - Autoantibodies/*blood
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Peptides, Cyclic/*immunology
MH  - Phenotype
MH  - Rheumatoid Factor/immunology
MH  - Turkey/epidemiology
EDAT- 2012/12/21 06:00
MHDA- 2013/05/31 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/05/31 06:00 [medline]
AID - 10.1111/j.1756-185X.2011.01604.x [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2012 Dec;15(6):538-45. doi: 10.1111/j.1756-185X.2011.01604.x. 
      Epub 2011 Mar 4.