PMID- 23253797 OWN - NLM STAT- MEDLINE DCOM- 20130429 LR - 20220331 IS - 1464-410X (Electronic) IS - 1464-4096 (Linking) VI - 111 IP - 3 DP - 2013 Mar TI - A nomogram predicting severe adverse events after ureteroscopic lithotripsy: 12 372 patients in a Japanese national series. PG - 459-66 LID - 10.1111/j.1464-410X.2012.11594.x [doi] AB - WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Ureteroscopic lithotripsy sometimes causes severe complications, e.g. septic shock, and the relationship between long operative duration and complication rate has been empirically recognised. But due to the rarity, evidence is limited. We analysed 12372 cases and showed that the complication rate increased according to operative duration, especially for operations taking >90 min. Also, we found that high-volume centres had lower complication rates. OBJECTIVE: To develop a nomogram to predict severe adverse events (AEs) after ureteroscopic lithotripsy (URSL) including the effects of operative duration and hospital volume. PATIENTS AND METHODS: We identified patients undergoing URSL from the Japanese Diagnosis Procedure Combination database between 2007 and 2010, and defined severe adverse events as (i) in-hospital mortality; (ii) postoperative medication including catecholamine, gamma globulin, protease inhibitors, medications for disseminated intravascular coagulation and transfusion; and (iii) postoperative interventions including percutaneous nephrostomy, central vein catheterisation, intensive care unit, dialysis, mechanical cardiopulmonary support. Univariate and multivariate logistic regression models addressed the occurrence of severe AEs. RESULTS: Of 12 372 patients, 296 patients (2.39%) had severe AEs. Multivariate analysis showed a positive linear trend of operative duration and severe AEs (odds ratio [OR] 1.58 in 90-119 min to OR 4.28 in >/=210 min compared with /=39 URSLs/year compared with