PMID- 23253950
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20130128
IS  - 0946-1965 (Print)
IS  - 0946-1965 (Linking)
VI  - 51
IP  - 2
DP  - 2013 Feb
TI  - Evaluation of adverse events associated with antiretroviral therapy and the 
      relationship to treatment adherence.
PG  - 141-6
LID - 10.5414/CP201818 [doi]
AB  - Despite the effectiveness of highly active antiretroviral therapy (HAART), many 
      adverse events (AEs) are associated with the use of these drugs, thus affecting 
      treatment adherence. The aim of this study was to evaluate AE incidence with the 
      use of HAART and the relationship to treatment adherence. This was a 
      retrospective observational study conducted with patients who experienced serious 
      AEs related to HAART, resulting in the need to change the therapeutic regimen. To 
      calculate adherence, the dates the patients received HAART were used. From 
      January 2009 to December 2011, 168 AE cases associated with antiretroviral drugs 
      were observed. Of the total study population, 58% of the patients were male. The 
      side effects were associated with 12 drugs, of which 58.3% were nucleoside 
      analogues reverse transcriptase inhibitors (NRTIs). In addition, 16.7% were 
      non-nucleoside reversetranscriptase inhibitors (NNRTIs), and 25% were protease 
      inhibitors (PIs). The NRTIs and PIs presented similar numbers of AEs, whereas the 
      NNRTIs resulted in less than 50% of the reported AEs compared to other drug 
      classes. The low adherence observed in patients with severe AEs that force 
      treatment regimen change suggests that the occurrence of side effects could be 
      one of the obstacles affecting the adherence and thus the effectiveness of HAART.
FAU - Lenzi, Luana
AU  - Lenzi L
AD  - Federal University of Parana, Curitiba, Parana, Brazil.
FAU - Wiens, Astrid
AU  - Wiens A
FAU - Pontarolo, Roberto
AU  - Pontarolo R
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Int J Clin Pharmacol Ther
JT  - International journal of clinical pharmacology and therapeutics
JID - 9423309
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Protease Inhibitors)
RN  - 0 (Reverse Transcriptase Inhibitors)
SB  - IM
MH  - Anemia/chemically induced
MH  - Anti-HIV Agents/*adverse effects
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Brazil
MH  - Female
MH  - Gastrointestinal Diseases/chemically induced
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Lipodystrophy/chemically induced
MH  - Male
MH  - Medication Adherence/*statistics & numerical data
MH  - Pancreatitis/chemically induced
MH  - Peripheral Nervous System Diseases/chemically induced
MH  - Protease Inhibitors/adverse effects
MH  - Retrospective Studies
MH  - Reverse Transcriptase Inhibitors/adverse effects
MH  - Skin Diseases/chemically induced
EDAT- 2012/12/21 06:00
MHDA- 2013/04/05 06:00
CRDT- 2012/12/21 06:00
PHST- 2013/01/24 00:00 [accepted]
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
AID - 10286 [pii]
AID - 10.5414/CP201818 [doi]
PST - ppublish
SO  - Int J Clin Pharmacol Ther. 2013 Feb;51(2):141-6. doi: 10.5414/CP201818.