PMID- 23254152
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20211021
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 62
IP  - 4
DP  - 2013 Apr 1
TI  - Adverse events in an integrated home-based treatment program for MDR-TB and HIV 
      in KwaZulu-Natal, South Africa.
PG  - 436-40
LID - 10.1097/QAI.0b013e31828175ed [doi]
AB  - Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are 
      HIV-infected, but the safety and tolerability of cotreatment are unknown. The 
      authors reviewed all adverse events (AEs) for patients with MDR-TB in a 
      home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB patients, 74 
      (81%) were HIV-positive and receiving antiretroviral therapy. AEs were common, 
      but most were mild and did not require therapy modification. The most common 
      severe AEs were hypothyroidism (36%) and psychosis (5%). Patients receiving 
      concurrent antiretroviral therapy did not experience AEs more frequently than 
      those on MDR-TB therapy alone. Concurrent treatment for MDR-TB/HIV can be safely 
      administered in a home-based care setting.
FAU - Brust, James C M
AU  - Brust JC
AD  - *Department of Medicine, Montefiore Medical Center and Albert Einstein College of 
      Medicine, Bronx, NY daggerPhilanjalo and Church of Scotland Hospital, Tugela Ferry, 
      South Africa double daggerCentre for the AIDS Programme of Research in South Africa 
      (CAPRISA), Durban, South Africa  section signDepartment of Epidemiology and Population 
      Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, 
      NY  ||Health Systems Research Unit, Medical Research Council, Cape Town, South 
      Africa  paragraph signDepartment of Medicine, Nelson R. Mandela School of Medicine, University 
      of KwaZulu-Natal, Durban, South Africa; Departments of #Medicine and 
      **Epidemiology, Yale University School of Medicine, New Haven, CT daggerdaggerDepartment of 
      Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA.
FAU - Shah, N Sarita
AU  - Shah NS
FAU - van der Merwe, Theo L
AU  - van der Merwe TL
FAU - Bamber, Sheila
AU  - Bamber S
FAU - Ning, Yuming
AU  - Ning Y
FAU - Heo, Moonseong
AU  - Heo M
FAU - Moll, Anthony P
AU  - Moll AP
FAU - Loveday, Marian
AU  - Loveday M
FAU - Lalloo, Umesh G
AU  - Lalloo UG
FAU - Friedland, Gerald H
AU  - Friedland GH
FAU - Gandhi, Neel R
AU  - Gandhi NR
LA  - eng
GR  - P30 AI051519/AI/NIAID NIH HHS/United States
GR  - R01 AI089349/AI/NIAID NIH HHS/United States
GR  - PEPFAR/PEPFAR/United States
GR  - R01 AI087465/AI/NIAID NIH HHS/United States
GR  - K23 AI083088/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Antitubercular Agents/adverse effects/*therapeutic use
MH  - HIV Infections/complications/*drug therapy
MH  - *Home Care Services
MH  - Humans
MH  - South Africa
MH  - Tuberculosis, Multidrug-Resistant/complications/*drug therapy
PMC - PMC3641171
MID - NIHMS433252
EDAT- 2012/12/21 06:00
MHDA- 2013/10/30 06:00
PMCR- 2014/04/01
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - 10.1097/QAI.0b013e31828175ed [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2013 Apr 1;62(4):436-40. doi: 
      10.1097/QAI.0b013e31828175ed.