PMID- 23254191
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20220408
IS  - 1471-0048 (Electronic)
IS  - 1471-003X (Linking)
VI  - 14
IP  - 1
DP  - 2013 Jan
TI  - Neurotrophin regulation of neural circuit development and function.
PG  - 7-23
LID - 10.1038/nrn3379 [doi]
AB  - Brain-derived neurotrophic factor (BDNF)--a member of a small family of secreted 
      proteins that includes nerve growth factor, neurotrophin 3 and neurotrophin 
      4--has emerged as a key regulator of neural circuit development and function. The 
      expression, secretion and actions of BDNF are directly controlled by neural 
      activity, and secreted BDNF is capable of mediating many activity-dependent 
      processes in the mammalian brain, including neuronal differentiation and growth, 
      synapse formation and plasticity, and higher cognitive functions. This Review 
      summarizes some of the recent progress in understanding the cellular and 
      molecular mechanisms underlying neurotrophin regulation of neural circuits. The 
      focus of the article is on BDNF, as this is the most widely expressed and studied 
      neurotrophin in the mammalian brain.
FAU - Park, Hyungju
AU  - Park H
AD  - Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills 
      Neuroscience Institute, University of California, Berkeley, California 94720, 
      USA.
FAU - Poo, Mu-ming
AU  - Poo MM
LA  - eng
GR  - EY014979/EY/NEI NIH HHS/United States
GR  - NS 036999/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Nat Rev Neurosci
JT  - Nature reviews. Neuroscience
JID - 100962781
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - *Brain/cytology/growth & development/metabolism
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Humans
MH  - Nerve Net/*physiology
MH  - Neurons/*metabolism
MH  - Synapses/physiology
EDAT- 2012/12/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - nrn3379 [pii]
AID - 10.1038/nrn3379 [doi]
PST - ppublish
SO  - Nat Rev Neurosci. 2013 Jan;14(1):7-23. doi: 10.1038/nrn3379.