PMID- 23254570
OWN - NLM
STAT- MEDLINE
DCOM- 20140103
LR  - 20130517
IS  - 1439-1899 (Electronic)
IS  - 0174-304X (Linking)
VI  - 44
IP  - 3
DP  - 2013 Jun
TI  - Pediatric multiple sclerosis with primary progressive course--report of a 
      retrospective cohort study in Iran.
PG  - 167-70
LID - 10.1055/s-0032-1329614 [doi]
AB  - The aims of this study were to suggest the rate of primary progressive (PP) 
      subtype of pediatric onset multiple sclerosis (MS) in Isfahan, Iran, and describe 
      its clinical and paraclinical features. The data of patients were retrieved from 
      Isfahan MS Society (IMSS) database from April 2003 to August 2011. Among 3,843 MS 
      patients of Isfahan who have been registered in IMSS, 260 patients had onset 
      symptom when younger than the age of 18 years, of whom, 11 patients had a PP 
      course (4.23%). The mean age at onset in pediatric primary progressive multiple 
      sclerosis (PPMS) was 16 years (range: 13 to 17) with female preponderance 
      (2.66:1) and disease duration of 4.73 +/- 3.03 years. Ataxia was the most frequent 
      initial symptom (7/11). Additionally, the mean Expanded Disability Status Scale 
      and progression index was 4.31 +/- 0.60 and 1.50 +/- 1.21, respectively. 
      Cerebrospinal fluid analysis showed oligoclonal immunoglobulin G bands in seven 
      patients. Magnetic resonance imaging (MRI) demonstrated periventricular lesions 
      in all 11 patients and spinal lesions in 9 patients. Exposure to parental smoking 
      was recorded in seven individuals. In conclusion, PPMS is an uncommon subtype of 
      pediatric onset MS. Cerebral lesions are more common MRI findings in pediatric 
      PPMS patients than that in adults. The course of PPMS seems to be more 
      progressive in the pediatric population than in adults.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Etemadifar, Masoud
AU  - Etemadifar M
AD  - Department of Neurology, Medical School, Isfahan University of Medical Sciences, 
      Isfahan, Islamic Republic of Iran.
FAU - Afzali, Parisa
AU  - Afzali P
FAU - Tabrizi, Nasim
AU  - Tabrizi N
FAU - Hosseini, Seyed-Alireza
AU  - Hosseini SA
LA  - eng
PT  - Journal Article
DEP - 20121219
PL  - Germany
TA  - Neuropediatrics
JT  - Neuropediatrics
JID - 8101187
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Cohort Studies
MH  - *Disease Progression
MH  - Female
MH  - Humans
MH  - Iran
MH  - Male
MH  - Multiple Sclerosis/cerebrospinal fluid/*physiopathology
MH  - Retrospective Studies
EDAT- 2012/12/21 06:00
MHDA- 2014/01/05 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2014/01/05 06:00 [medline]
AID - 10.1055/s-0032-1329614 [doi]
PST - ppublish
SO  - Neuropediatrics. 2013 Jun;44(3):167-70. doi: 10.1055/s-0032-1329614. Epub 2012 
      Dec 19.