PMID- 23255011
OWN - NLM
STAT- MEDLINE
DCOM- 20130212
LR  - 20181202
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Linking)
VI  - 42
IP  - 12
DP  - 2012 Dec
TI  - Spotlight on NKG2C and the human NK-cell response to CMV infection.
PG  - 3141-5
LID - 10.1002/eji.201243050 [doi]
AB  - Immune responses to cytomegalovirus (CMV) infection in the mouse and human 
      involve the expansion of specific subsets of natural killer (NK) cells with 
      specific phenotypic characteristics and a heightened ability to produce 
      interferon (IFN)-gamma. In humans, these NK-cell responses are largely driven by 
      the activating receptor NKG2C, which recognize human leukocyte antigen (HLA)-E in 
      complex with leader sequence peptides. In this issue of the European Journal of 
      Immunology, Noyola et al. [Eur. J. Immunol. 2012, 42: 3256-3266] examine NK-cell 
      responses in a unique cohort of young children with asymptomatic and symptomatic 
      congenital CMV infection. They also address NK-cell responses to CMV in relation 
      to NKG2C gene copy number. Children with a symptomatic congenital infection 
      exhibited a marked expansion of NKG2C(+) NK cells. However, despite having 
      slightly lower frequencies of NKG2C(+) NK cells, children with a heterozygous 
      deletion of the NKG2C gene seemed to control the virus as efficiently as those 
      with two copies of the NKG2C gene. The present studies shed new light on the role 
      of NKG2C copy number variation on the human NK-cell response to CMV infection.
CI  - (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Malmberg, Karl-Johan
AU  - Malmberg KJ
AD  - Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden. 
      kalle.malmberg@ki.se
FAU - Beziat, Vivien
AU  - Beziat V
FAU - Ljunggren, Hans-Gustaf
AU  - Ljunggren HG
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (KLRC2 protein, human)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily C)
SB  - IM
CON - Eur J Immunol. 2012 Dec;42(12):3256-66. PMID: 22965785
MH  - Cytomegalovirus/*immunology
MH  - Cytomegalovirus Infections/*congenital/*immunology
MH  - Female
MH  - Gene Expression Regulation/*immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Male
MH  - NK Cell Lectin-Like Receptor Subfamily C/*immunology
EDAT- 2012/12/21 06:00
MHDA- 2013/02/13 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/10/06 00:00 [received]
PHST- 2012/10/06 00:00 [revised]
PHST- 2012/10/18 00:00 [accepted]
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/02/13 06:00 [medline]
AID - 10.1002/eji.201243050 [doi]
PST - ppublish
SO  - Eur J Immunol. 2012 Dec;42(12):3141-5. doi: 10.1002/eji.201243050.