PMID- 23255668
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20221207
IS  - 0231-5882 (Print)
IS  - 0231-5882 (Linking)
VI  - 31
IP  - 4
DP  - 2012 Dec
TI  - Analysis of genetic polymorphisms of brain-derived neurotrophic factor and 
      methylenetetrahydrofolate reductase in depressed patients in a Slovak (Caucasian) 
      population.
PG  - 415-22
LID - 10.4149/gpb_2012_049 [doi]
AB  - Major depressive disorder (MDD) is a complex neuropsychiatric disorder where both 
      gene-gene and gene-environment interactions play an important role, but the clues 
      are still not fully understood. One carbon metabolism in the CNS plays a critical 
      role in the synthesis and release of neurotransmitters which are relevant to 
      depressive disorder. We studied genetic polymorphisms of the brain derived 
      neurotrophic factor (BDNF) and the methylenetetrahydrofolate reductase (MTHFR) in 
      association with major depressive disorder. We genotyped the BDNF G196A, the 
      MTHFR C677T, and A1298C polymorphisms in 134 patients diagnosed with major 
      depression and 143 control subjects in Slovak (Caucasian) cohort of patients and 
      probands. We found no significant association of either the BDNF G196A or MTHFR 
      C677T polymorphisms with major depressive disorder neither in female nor male 
      group of patients. However, the MTHFR A1298C genotype distribution was 36.6% (for 
      AA genotype), 48.5% (AC) and 14.9% (CC) for the depressed patients, and 48.9% 
      (AA), 42.7% (AC) and 8.4% (CC), respectively, for the control subjects. Patients 
      with MDD had a higher prevalence of the CC genotype (OR = 2.38; 95% CI = 
      1.07-5.32; p = 0.032) and the AC + CC genotype (OR = 1.67; 95% CI = 1.03-2.69; p 
      = 0.037) in comparison with the control subjects. This study shows that CC 
      genotype of the MTHFR A1298C is associated with higher risk of MDD in Slovak 
      population.
FAU - Evinova, Andrea
AU  - Evinova A
AD  - Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, 
      Comenius University Bratislava, Slovak Republic.
FAU - Babusikova, Eva
AU  - Babusikova E
FAU - Straka, Stanislav
AU  - Straka S
FAU - Ondrejka, Igor
AU  - Ondrejka I
FAU - Lehotsky, Jan
AU  - Lehotsky J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Slovakia
TA  - Gen Physiol Biophys
JT  - General physiology and biophysics
JID - 8400604
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Genetic Markers)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Depression/*epidemiology/*genetics
MH  - Female
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/*epidemiology/*genetics
MH  - Humans
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Prevalence
MH  - Risk Factors
MH  - Slovakia/epidemiology
MH  - White People/statistics & numerical data
MH  - Young Adult
EDAT- 2012/12/21 06:00
MHDA- 2013/03/08 06:00
CRDT- 2012/12/21 06:00
PHST- 2012/12/21 06:00 [entrez]
PHST- 2012/12/21 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - 10.4149/gpb_2012_049 [doi]
PST - ppublish
SO  - Gen Physiol Biophys. 2012 Dec;31(4):415-22. doi: 10.4149/gpb_2012_049.