PMID- 23255885 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220316 IS - 1792-1074 (Print) IS - 1792-1082 (Electronic) IS - 1792-1074 (Linking) VI - 5 IP - 1 DP - 2013 Jan TI - Updates on the cytogenetics and molecular cytogenetics of benign and intermediate soft tissue tumors. PG - 12-18 AB - SOFT TISSUE TUMORS ARE CLASSIFIED ACCORDING TO THEIR HISTOLOGICAL RESEMBLANCE TO NORMAL ADULT TISSUES AND CAN BE GROUPED INTO THE FOLLOWING CATEGORIES BASED ON METASTATIC POTENTIAL: benign, intermediate (locally aggressive), intermediate (rarely metastasizing) and malignant. Over the past two decades, considerable progress has been made in our understanding of the genetic background of soft tissue tumors. Traditional laboratory techniques, such as cytogenetic analysis and fluorescence in situ hybridization (FISH), can be used for diagnostic purposes in soft tissue pathology practice. Moreover, cytogenetic and molecular studies are often necessary for prognostics and follow-up of soft tissue sarcoma patients. This review provides updated information on the applicability of laboratory genetic testing in the diagnosis of benign and intermediate soft tissue tumors. These tumors include nodular fasciitis, chondroid lipoma, collagenous fibroma (desmoplastic fibroblastoma), giant cell tumor of tendon sheath (GCTTS)/pigmented villonodular synovitis (PVNS), angiofibroma of soft tissue, myxoinflammatory fibroblastic sarcoma (MIFS) and ossifying fibromyxoid tumor (OFMT). FAU - Nishio, Jun AU - Nishio J AD - Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan. LA - eng PT - Journal Article DEP - 20121030 PL - Greece TA - Oncol Lett JT - Oncology letters JID - 101531236 PMC - PMC3525488 EDAT- 2012/12/21 06:00 MHDA- 2012/12/21 06:01 PMCR- 2012/10/30 CRDT- 2012/12/21 06:00 PHST- 2012/09/10 00:00 [received] PHST- 2012/10/04 00:00 [accepted] PHST- 2012/12/21 06:00 [entrez] PHST- 2012/12/21 06:00 [pubmed] PHST- 2012/12/21 06:01 [medline] PHST- 2012/10/30 00:00 [pmc-release] AID - ol-05-01-0012 [pii] AID - 10.3892/ol.2012.1002 [doi] PST - ppublish SO - Oncol Lett. 2013 Jan;5(1):12-18. doi: 10.3892/ol.2012.1002. Epub 2012 Oct 30.