PMID- 23257028
OWN - NLM
STAT- MEDLINE
DCOM- 20140110
LR  - 20211203
IS  - 1001-9391 (Print)
IS  - 1001-9391 (Linking)
VI  - 30
IP  - 11
DP  - 2012 Nov
TI  - [Effects of human umbilical cord mesenchymal stem cells in the treatment of 
      paraquat-induced lung injury].
PG  - 811-5
AB  - OBJECTIVE: To evaluate the clinical effect and safety of human umbilical cord 
      mesenchymal stem cells (HUCMSCs) in the treatment of lung injury caused by acute 
      paraquat poisoning. METHODS: Thirteen patients with lung injury caused by acute 
      paraquat poisoning, who were admitted to Guangzhou No. 12 People's Hospital from 
      December 2008 to December 2012, were divided into HUCMSC group (n = 5) and 
      control group (n = 8). All patients received conventional treatment, while the 
      HUCMSC group was treated with HUCMSCs as an addition. Sequential Organ Failure 
      Assessment (SOFA) system, which was created by the Infection Section of European 
      Society of Intensive Care Medicine, and Acute Physiology and Chronic Health 
      Evaluation II were used to acquire the SOFA scores of patients. The lung injury 
      was evaluated with lung injury score (LIS). The two groups were compared with 
      respect to maximum SOFA scores at 1, 3, 5, 7, 14, and 15 days after paraquat 
      poisoning. RESULTS: The HUCMSC group showed significantly lower maximum SOFA 
      scores than the control group at 15d after poisoning (1.80 +/- 2.05 vs 13.50 +/- 
      7.59, P < 0.05). The LISs of the HUCMSC group after treatment (0.45 +/- 0.27) were 
      significantly lower than those of the HUCMSC group before treatment (1.15 +/- 0.34) 
      and those of the control group after treatment (2.94 +/- 1.20) (P < 0.01). In the 
      HUCMSC group, all patients survived, and they complained no discomfort and showed 
      normal liver, kidney, and lung functions in reexamination; one patient showed 
      incompletely absorbed shadow in the posterior segment of the left lower lobe of 
      the lung during lung CT scan, and no abnormal findings were seen in other 
      patients. In the control group, one patient survived, and others died. No adverse 
      reactions, such as chill and fever, were presented in the HUCMSC group. 
      CONCLUSION: HUCMSCs show promise for clinical application in the treatment of 
      lung injury caused by acute paraquat poisoning.
FAU - Liu, Wei-wei
AU  - Liu WW
AD  - Guangzhou 12th Municipal People's Hospital, Guangzhou 510620, China.
FAU - Yu, Wei
AU  - Yu W
FAU - Chen, Jia-yu
AU  - Chen JY
FAU - Ye, Geng-xin
AU  - Ye GX
FAU - Liu, Yi-ming
AU  - Liu YM
FAU - Chen, Lin-zhen
AU  - Chen LZ
FAU - Chen, Yun-xian
AU  - Chen YX
FAU - Zhang, Cheng
AU  - Zhang C
FAU - Zhong, Xue-yun
AU  - Zhong XY
LA  - chi
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - China
TA  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi
JT  - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng 
      zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
JID - 8410840
RN  - PLG39H7695 (Paraquat)
RN  - Paraquat lung
SB  - IM
MH  - Acute Lung Injury
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Humans
MH  - Lung Injury/chemically induced/therapy
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Paraquat/poisoning
MH  - Pulmonary Edema/*therapy
MH  - Treatment Outcome
MH  - Umbilical Cord/cytology
MH  - Young Adult
EDAT- 2012/12/22 06:00
MHDA- 2014/01/11 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2014/01/11 06:00 [medline]
PST - ppublish
SO  - Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Nov;30(11):811-5.