PMID- 23258316
OWN - NLM
STAT- MEDLINE
DCOM- 20140326
LR  - 20161125
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 14
IP  - 8
DP  - 2013 Aug
TI  - Global and regional longitudinal strain assessed by two-dimensional speckle 
      tracking echocardiography identifies early myocardial dysfunction and transmural 
      extent of myocardial scar in patients with acute ST elevation myocardial 
      infarction and relatively preserved LV function.
PG  - 805-11
LID - 10.1093/ehjci/jes295 [doi]
AB  - AIMS: Global and regional longitudinal strain (GLS-RLS) assessed by 
      two-dimensional speckle tracking echocardiography (2D-STE) are considered 
      reliable indexes of left-ventricular (LV) function and myocardial viability in 
      chronic ischaemic patients when compared with delayed-enhanced cardiac magnetic 
      resonance (DE-CMR). In the present study, we tested whether GLS and RLS could 
      also identify early myocardial dysfunction and transmural extent of myocardial 
      scar in patients with acute ST elevation myocardial infarction (STEMI) and 
      relatively preserved LV function. METHODS AND RESULTS: Twenty STEMI patients with 
      LVEF >/=40%, treated with PPCI within 6 h from symptoms onset, underwent DE-CMR and 
      2D-echocardiography for 2D-STE analysis 6 +/- 2 days after STEMI. Wall motion score 
      index (WMSI) and LV ejection fraction (LVEF) were calculated by both methods. 
      Infarct size and transmural extent of necrosis were assessed by CMR. GLS and RLS 
      were obtained by 2D-STE. Mean GLS of the study population was -14 +/- 3.3, showing 
      a significant correlation with both LVEF and WMSI, by CMR (r = -0.86, P = 0.001, 
      and r = 0.80, P = 0.001, respectively) and time-to-PCI (r = 0.66, P = 0.038). A 
      weaker correlation was found between GLS and LVEF and WMSI assessed by 2D-echo (r 
      = -0.65, P = 0.001, and r = 0.53, P = 0.013, respectively). RLS was significantly 
      lower in DE-segments when compared with normal myocardium (P < 0.0001). A cut-off 
      value of RLS of -12.3% by receiver-operating characteristic (ROC) curves 
      identified DE-segments (sensitivity 82%, specificity 78%), whereas a cut-off 
      value of -11.5% identified transmural extent of DE (sensitivity 75%, specificity 
      78%). CONCLUSION: Our findings indicate that RLS and GLS evaluation provides an 
      accurate assessment of global myocardial function and of the presence of segments 
      with transmural extent of necrosis, with several potential clinical implications.
FAU - Cimino, S
AU  - Cimino S
AD  - Department of Cardiology, Sapienza University of Rome, Roma, Italy.
FAU - Canali, E
AU  - Canali E
FAU - Petronilli, V
AU  - Petronilli V
FAU - Cicogna, F
AU  - Cicogna F
FAU - De Luca, L
AU  - De Luca L
FAU - Francone, M
AU  - Francone M
FAU - Sardella, G
AU  - Sardella G
FAU - Iacoboni, C
AU  - Iacoboni C
FAU - Agati, L
AU  - Agati L
LA  - eng
PT  - Journal Article
DEP - 20121220
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 15G12L5X8K (gadobenic acid)
RN  - 6HG8UB2MUY (Meglumine)
SB  - IM
MH  - Cicatrix/diagnostic imaging/physiopathology
MH  - Contrast Media
MH  - Echocardiography/*methods
MH  - Echocardiography, Doppler
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Meglumine/analogs & derivatives
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnostic imaging/*physiopathology/therapy
MH  - Organometallic Compounds
MH  - Risk Factors
MH  - Ventricular Dysfunction, Left/*diagnostic imaging/*physiopathology/therapy
OTO - NOTNLM
OT  - Cardiac magnetic resonance (CMR)
OT  - Global longitudinal strain (GLS)
OT  - Regional longitudinal strain (RLS)
OT  - ST elevated myocardial infarction (STEMI)
OT  - Two-dimensional speckle tracking echocardiography (2D-STE)
EDAT- 2012/12/22 06:00
MHDA- 2014/03/29 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - jes295 [pii]
AID - 10.1093/ehjci/jes295 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2013 Aug;14(8):805-11. doi: 10.1093/ehjci/jes295. 
      Epub 2012 Dec 20.