PMID- 23258325
OWN - NLM
STAT- MEDLINE
DCOM- 20150516
LR  - 20181202
IS  - 0371-0874 (Print)
IS  - 0371-0874 (Linking)
VI  - 64
IP  - 6
DP  - 2012 Dec 25
TI  - [The antiepileptic role of 3alpha-androstanediol on the epileptic rats induced by 
      pentylenetetrazole].
PG  - 633-8
AB  - The influence of 3alpha-androstanediol (3alpha-diol) on twitch and electroencephalogram 
      (EEG) of the epileptic rats induced by pentylenetetrazole (PTZ) has been observed 
      in this experiment in order to comprehensively explore the role of 3alpha-diol on 
      epileptic attack from the aspects of behavior and EEG. Thirty-two male 
      Sprague-Dawley rats were evenly and randomly divided into 4 groups: the normal 
      and supplied with oil epileptic (N+oil+PTZ) group, the normal and supplied with 
      3alpha-diol epileptic (N+3alpha-diol+PTZ) group, the gonadectomized and supplied with oil 
      epileptic (GDX+oil+PTZ) group and the gonadectomized and supplied with 3alpha-diol 
      epileptic (GDX+3alpha-diol+PTZ) group. The changes of the behavior and EEG of 
      epileptic rats in every group were recorded and analyzed. The results of behavior 
      observation showed that the latency to clonic seizure and tonic-clonic seizure 
      was shortened and the number of tonic-clonic seizure was increased significantly 
      in the GDX+oil+PTZ group in comparison with N+oil+PTZ group (P < 0.05); comparing 
      GDX+3alpha-diol+PTZ group with GDX+oil+PTZ group, or N+3alpha-diol+PTZ group with 
      N+oil+PTZ group, we found that the latency to clonic seizure and tonic-clonic 
      seizure became prolonged significantly, and the number of clonic seizure and 
      tonic-clonic seizure was decreased significantly (P < 0.05). The results of EEG 
      showed that the latency to epileptic waves was cut and the number of epileptic 
      waves was augmented significantly in the GDX+oil+PTZ group in comparison with 
      N+oil+PTZ group (P < 0.05); comparing GDX+3alpha-diol+PTZ group with GDX+oil+PTZ 
      group, or N+3alpha-diol+PTZ group with N+oil+PTZ group, we found that the latency to 
      epileptic waves became lengthened significantly, the number of epileptic waves 
      was reduced significantly and the percentage of change of TP (total power of 
      spectrum) was lessened significantly (P < 0.05). These results indicate that 
      3alpha-diol has an antiepileptic activity in the gonadectomized and normal epileptic 
      rats.
FAU - Zhang, Yu-Hao
AU  - Zhang YH
AD  - Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, 
      China.
FAU - Cao, Yin-Xiang
AU  - Cao YX
FAU - Ma, Yu
AU  - Ma Y
FAU - Guo, Xi
AU  - Guo X
FAU - Wang, Xin
AU  - Wang X
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sheng Li Xue Bao
JT  - Sheng li xue bao : [Acta physiologica Sinica]
JID - 20730130R
RN  - 0 (Anticonvulsants)
RN  - 25126-76-5 (Androstane-3,17-diol)
RN  - 27195-25-1 (androstane-3,17-diol glucuronide)
RN  - WM5Z385K7T (Pentylenetetrazole)
SB  - IM
MH  - Androstane-3,17-diol/*analogs & derivatives/pharmacology
MH  - Animals
MH  - Anticonvulsants/*pharmacology
MH  - Electroencephalography
MH  - Epilepsy/chemically induced/*drug therapy
MH  - Male
MH  - Pentylenetetrazole/*adverse effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seizures/chemically induced/*drug therapy
EDAT- 2012/12/22 06:00
MHDA- 2015/05/20 06:00
CRDT- 2012/12/22 06:00
PHST- 2012/12/22 06:00 [entrez]
PHST- 2012/12/22 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
PST - ppublish
SO  - Sheng Li Xue Bao. 2012 Dec 25;64(6):633-8.