PMID- 23259206
OWN - NLM
STAT- MEDLINE
DCOM- 20130110
LR  - 20160413
IS  - 0011-4162 (Print)
IS  - 0011-4162 (Linking)
VI  - 90
IP  - 4
DP  - 2012 Oct
TI  - Clinical application and limitations of the fluorescence in situ hybridization 
      (FISH) assay in the diagnosis and management of melanocytic lesions: a report of 
      3 cases.
PG  - 189-95
AB  - Histopathologic examination is the gold standard for the diagnosis of melanocytic 
      lesions, including melanoma, and guides management options and disease prognosis 
      based on the depth of invasion. Although most melanomas can be readily 
      distinguished from benign nevi, some pigmented lesions are more ambiguous and can 
      be challenging to interpret as truly benign or truly malignant. Unfortunately, 
      misclassification can render severe consequences for the patient, making it 
      imperative to explore further analysis to determine the true nature of an 
      ambiguous lesion. A relatively new technique known as fluorescence in situ 
      hybridization (FISH) has become prevalent in dermatopathology for distinguishing 
      between benign and malignant pigmented lesions; however, there are few reports on 
      the application of FISH results in the clinical setting. We present 3 cases in 
      which a FISH assay was utilized to assist in the diagnosis and management of 
      ambiguous pigmented lesions. We also provide a review of the most recent 
      literature regarding this diagnostic modality.
FAU - Nijhawan, Rajiv I
AU  - Nijhawan RI
AD  - Department of Dermatology, Beth Israel Medical Center, New York, New York, USA.
FAU - Votava, Henry J
AU  - Votava HJ
FAU - Mariwalla, Kavita
AU  - Mariwalla K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cutis
JT  - Cutis
JID - 0006440
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Melanocytes/*pathology
MH  - Melanoma/*diagnosis/pathology/therapy
MH  - Middle Aged
MH  - Skin Neoplasms/*diagnosis/pathology/therapy
MH  - Young Adult
EDAT- 2012/12/25 06:00
MHDA- 2013/01/11 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/01/11 06:00 [medline]
PST - ppublish
SO  - Cutis. 2012 Oct;90(4):189-95.