PMID- 23259295
OWN - NLM
STAT- MEDLINE
DCOM- 20130520
LR  - 20161125
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 26
IP  - 18
DP  - 2012 Sep
TI  - [Expression and clinical significance of MDM2 and P16 in laryngeal squamous cell 
      carcinoma].
PG  - 802-5
AB  - OBJECTIVE: To investigate the relationship between the protein expression of MDM2 
      and P16 in laryngeal squamous cell carcinoma (LSCC), and their relationship with 
      clinic pathological feature. METHOD: The expression of MDM2 and P16 were detected 
      by S-P immunohistochemical method with mouse monoclonal anti MDM2 antibody and 
      anti P16 antibody in 35 LSCC specimens, 21 specimens of precancerous larynx, 20 
      normal laryngeal specimens. RESULT: Expression of MDM2 positive in normal 
      laryngeal specimens, precancerous larynx and LSCC specimens were 10.0%, 38.1%, 
      54.3% respectively (P < 0.05), and in I - III pathological grade laryngeal 
      carcinoma were 38.1%, 66.7%, 100.0% respectively (P < 0.05); Expression of P16 
      positive in normal laryngeal specimens, precancerous larynx and LSCC specimens 
      were 85.1%, 52.4%, 34.3% respectively (P < 0.05), and in I - III pathological 
      grade laryngeal carcinoma were 52.4%, 11.1%, 0% respectively (P < 0.05). 
      CONCLUSION: Expression of MDM2 positive were higher with lower differentiation, 
      so it's maybe helpful to diagnose LSCC. Expression of P16 positive were lower 
      with lower differentiation, and there's no expression in III pathological grade 
      LSCC, so it has positive effect on malignancy determination. Abnormal expression 
      of MDM2 and P16 have different effects on LSCC development. Expression of MDM2 
      and P16 have negative correlation in LSCC.
FAU - Li, Dawei
AU  - Li D
AD  - Department of Otolaryngology-Head and Neck Surgery, Dalian Municipal Central 
      Hospital, Dalian116033, China. lingfeng887463@sina.com
FAU - Zhang, Qingfeng
AU  - Zhang Q
FAU - Zhang, Xinran
AU  - Zhang X
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - EC 2.3.2.27 (MDM2 protein, human)
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/*pathology
MH  - Cyclin-Dependent Kinase Inhibitor p16/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/*pathology
MH  - Middle Aged
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-mdm2/*metabolism
EDAT- 2012/12/25 06:00
MHDA- 2013/05/22 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/05/22 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Sep;26(18):802-5.