PMID- 23260857
OWN - NLM
STAT- MEDLINE
DCOM- 20130628
LR  - 20220408
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 99
IP  - 5
DP  - 2013 Apr
TI  - Preimplantation genetic screening using fluorescence in situ hybridization in 
      patients with repetitive implantation failure and advanced maternal age: 
      two randomized trials.
PG  - 1400-7
LID - S0015-0282(12)02453-3 [pii]
LID - 10.1016/j.fertnstert.2012.11.041 [doi]
AB  - OBJECTIVE: To evaluate the usefulness of preimplantation genetic screening (PGS) 
      using fluorescence in situ hybridization (FISH) for two different indications: 
      repetitive implantation failure (RIF) and advanced maternal age (AMA). DESIGN: 
      Two prospective, randomized controlled trials with patients allocated in two 
      arms: blastocyst transfer on day 5 (group A) or PGS with transfer on day 5 (group 
      B). SETTING: University-affiliated private clinics. PATIENT(S): The RIF study 
      included women <40 years with three or more failed IVF cycles without other known 
      causal factors (91 patients). The AMA study included intracytoplasmic sperm 
      injection patients aged between 41 and 44 (183 patients). INTERVENTION(S): In the 
      PGS group, single-cell day 3 biopsy was performed with aneuploidy screening for 
      chromosomes 13, 15, 16, 17, 18, 21, 22, X, and Y. In both the blastocyst transfer 
      group and the PGS group, ET was performed on day 5. MAIN OUTCOME MEASURE(S): 
      Live-birth rate per patient and per started cycle. RESULT(S): A significant 
      increase in live-birth rates per patient was found in the PGS group compared with 
      the blastocyst group for the AMA study (30/93 patients [32.3%] vs. 14/90 patients 
      [15.5%]; odds ratio, 2.585; confidence interval, [1.262-5.295]). In the RIF study 
      no significant differences were observed (23/48 patients [47.9%] vs. 12/43 
      patients [27.9%]). CONCLUSION(S): PGS with FISH was shown to be beneficial for 
      the AMA group.
CI  - Copyright (c) 2013 American Society for Reproductive Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Rubio, Carmen
AU  - Rubio C
AD  - Instituto Valenciano de Infertilidad (IVI), Instituto Universitario IVI, Valencia 
      University, INCLIVA, Valencia, Spain. carmen.rubio@iviomics.com
FAU - Bellver, Jose
AU  - Bellver J
FAU - Rodrigo, Lorena
AU  - Rodrigo L
FAU - Bosch, Ernesto
AU  - Bosch E
FAU - Mercader, Amparo
AU  - Mercader A
FAU - Vidal, Carmen
AU  - Vidal C
FAU - De los Santos, Maria Jose
AU  - De los Santos MJ
FAU - Giles, Juan
AU  - Giles J
FAU - Labarta, Elena
AU  - Labarta E
FAU - Domingo, Javier
AU  - Domingo J
FAU - Crespo, Juana
AU  - Crespo J
FAU - Remohi, Jose
AU  - Remohi J
FAU - Pellicer, Antonio
AU  - Pellicer A
FAU - Simon, Carlos
AU  - Simon C
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20121220
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
CIN - Fertil Steril. 2013 Apr;99(5):1205-6. PMID: 23415971
MH  - Adult
MH  - Aneuploidy
MH  - Embryo Culture Techniques
MH  - *Embryo Implantation
MH  - Embryo Transfer/*methods
MH  - Female
MH  - Genetic Testing/methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Infertility, Female/*therapy
MH  - *Maternal Age
MH  - Pregnancy
MH  - Pregnancy Rate
MH  - Preimplantation Diagnosis/*methods
MH  - Prospective Studies
MH  - Treatment Failure
EDAT- 2012/12/25 06:00
MHDA- 2013/07/03 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/06/04 00:00 [received]
PHST- 2012/11/14 00:00 [revised]
PHST- 2012/11/20 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - S0015-0282(12)02453-3 [pii]
AID - 10.1016/j.fertnstert.2012.11.041 [doi]
PST - ppublish
SO  - Fertil Steril. 2013 Apr;99(5):1400-7. doi: 10.1016/j.fertnstert.2012.11.041. Epub 
      2012 Dec 20.