PMID- 23261238
OWN - NLM
STAT- MEDLINE
DCOM- 20130812
LR  - 20151119
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 209
IP  - 2
DP  - 2013 Feb 15
TI  - Elevated expression of integrin alphav and beta5 subunit in laryngeal squamous-cell 
      carcinoma associated with lymphatic metastasis and angiogenesis.
PG  - 105-9
LID - S0344-0338(12)00322-6 [pii]
LID - 10.1016/j.prp.2012.11.001 [doi]
AB  - In the past several years, the alphav integrin subfamily has been repeatedly found to 
      be involved in tumor progression and angiogenesis. The aim of this study was to 
      investigate the expression of the integrin alphav subfamily in laryngeal squamous 
      cell carcinoma (LSCC), and to correlate the expression rate with tumor biological 
      behavior and angiogenesis of the LSCC. The integrin alphav subfamily, including alphav, 
      beta1, beta3, beta5, beta6 and beta8 subunits, was immunohistochemically found to be expressed 
      in 64 patients with LSCC, and we analyzed the relationship between the expression 
      rate and the clinicopathological stage of this cancer. Immunohistochemical 
      staining for CD105 was carried out in the same group of the patients. The 
      intratumoral microvessel density (IMVD) of the LSCC was calculated by CD105 
      staining, and the correlation between the IMVD and alphav subfamily expression was 
      discussed. The results showed that all members of the integrin alphav subfamily could 
      be detected in the LSCC. The expression rate of integrin alphav and beta5 subunits in 
      primary cancer was significantly higher than in normal tissue, and their 
      expression rate in the group with lymphatic metastasis was significantly higher 
      than in the group without metastasis. The IMVD of the group with positive 
      expression of alphav and beta5 subunits was significantly higher than in the group with 
      negative expression, but there were no significant effects on the beta1, beta3, beta6 and 
      beta8 subunits in these biological processes. In conclusion, the expressions of 
      integrin alphav and beta5 subunits were significantly associated with lymphatic 
      metastasis and angiogenesis of the LSCC. Among the members of integrin alphav 
      subfamily, integrin alphavbeta5 might play an important role in invasion and metastases 
      of the LSCC, and it may become a valuable marker for the evolution of the LSCC.
CI  - Copyright (c) 2012 Elsevier GmbH. All rights reserved.
FAU - Li, Feng
AU  - Li F
AD  - Department of Otolaryngology/Head and Neck Surgery, Second Affiliated Hospital of 
      Harbin Medical University, Harbin 150081, PR China.
FAU - Liu, Ying
AU  - Liu Y
FAU - Kan, Xuan
AU  - Kan X
FAU - Li, Yong
AU  - Li Y
FAU - Liu, Ming
AU  - Liu M
FAU - Lu, Jian Guang
AU  - Lu JG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121220
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Receptors, Vitronectin)
RN  - 0 (integrin alphaVbeta5)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma, Squamous Cell/*metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*metabolism/*pathology
MH  - Lymphatic Metastasis/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Neovascularization, Pathologic/metabolism/pathology
MH  - Receptors, Vitronectin/analysis/*biosynthesis
EDAT- 2012/12/25 06:00
MHDA- 2013/08/13 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/04/26 00:00 [received]
PHST- 2012/10/17 00:00 [revised]
PHST- 2012/11/05 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/08/13 06:00 [medline]
AID - S0344-0338(12)00322-6 [pii]
AID - 10.1016/j.prp.2012.11.001 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2013 Feb 15;209(2):105-9. doi: 10.1016/j.prp.2012.11.001. Epub 
      2012 Dec 20.