PMID- 23261675
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20240109
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 53
DP  - 2013 Mar
TI  - Dieckol isolated from brown seaweed Ecklonia cava attenuates type capital I, Ukrainiancapital I, Ukrainian diabetes in 
      db/db mouse model.
PG  - 294-8
LID - S0278-6915(12)00885-X [pii]
LID - 10.1016/j.fct.2012.12.012 [doi]
AB  - In the present study, the attenuation of type capital I, Ukrainiancapital I, Ukrainian diabetes by dieckol, a 
      phlorotannin derivative isolated from brown seaweed, Ecklonia cava was 
      investigated in C57BL/KsJ-db/db, a type capital I, Ukrainiancapital I, Ukrainian diabetes mouse model. Dieckol was 
      administered intraperitoneal injection at doses of 10 and 20 mg/kg body weight 
      diabetes mice for 14 days. The blood glucose level, serum insulin level and body 
      weight were significantly reduced in the dieckol administered group, compared to 
      that of the saline administered group. Furthermore, reduced thiobarbituric acid 
      reactive substraces (TBARS), as well as increased activities of antioxidant 
      enzymes, including superoxide dismutase (SOD), catalase (CAT) and glutathione 
      peroxidase (GSH-px) in liver tissues were observed in the dieckol administered 
      group. In addition, increased levels of the phosphorylation of AMPK and Akt were 
      observed in the muscle tissues of the dieckol administered group in a Western 
      blotting analysis. According to the findings of this study, it could be suggested 
      that, dieckol can be developed as a therapeutic agent for type capital I, Ukrainiancapital I, Ukrainian diabetes.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Kang, Min-Cheol
AU  - Kang MC
AD  - Department of Marine Life Sciences, Jeju National University, Jeju 690-756, 
      Republic of Korea.
FAU - Wijesinghe, W A J P
AU  - Wijesinghe WA
FAU - Lee, Seung-Hong
AU  - Lee SH
FAU - Kang, Sung-Myung
AU  - Kang SM
FAU - Ko, Seok-Chun
AU  - Ko SC
FAU - Yang, Xiudong
AU  - Yang X
FAU - Kang, Nalae
AU  - Kang N
FAU - Jeon, Byong-Tae
AU  - Jeon BT
FAU - Kim, Jaell
AU  - Kim J
FAU - Lee, Dae-Ho
AU  - Lee DH
FAU - Jeon, You-Jin
AU  - Jeon YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121220
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Benzofurans)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 0 (dieckol)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinases/genetics/metabolism
MH  - Animals
MH  - Benzofurans/*administration & dosage/isolation & purification
MH  - Blood Glucose/analysis/drug effects
MH  - Body Weight/drug effects
MH  - Catalase/metabolism
MH  - Diabetes Mellitus, Experimental/*drug therapy
MH  - Disease Models, Animal
MH  - Glutathione Peroxidase/metabolism
MH  - Hypoglycemic Agents/*administration & dosage/isolation & purification
MH  - Insulin/blood
MH  - Lipid Peroxidation/drug effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phaeophyceae/*chemistry
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins c-akt/genetics/metabolism
MH  - Seaweed/*chemistry
MH  - Signal Transduction
MH  - Superoxide Dismutase/metabolism
EDAT- 2012/12/25 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/08/14 00:00 [received]
PHST- 2012/11/01 00:00 [revised]
PHST- 2012/12/08 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - S0278-6915(12)00885-X [pii]
AID - 10.1016/j.fct.2012.12.012 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2013 Mar;53:294-8. doi: 10.1016/j.fct.2012.12.012. Epub 2012 
      Dec 20.