PMID- 23262096
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20190923
IS  - 0253-9772 (Print)
IS  - 0253-9772 (Linking)
VI  - 34
IP  - 12
DP  - 2012 Dec
TI  - [Association between human leukocyte antigen and nasopharyngeal-carcinoma].
PG  - 1505-12
AB  - Nasopharyngeal carcinoma (NPC) is characterized by its distinct racial and 
      geographical distribution with a multifactorial etiology. It has been well 
      accepted that NPC is related to Epstein-Barr(EB) virus infection but 
      environmental and genetics factors also play critical roles. Among host genetic 
      markers associated with NPC, the highly variable class I human leukocyte antigen 
      (HLA) genes on chromosome 6 (6p21.3) have shown a strong and consistent 
      association with NPC risk. As the consequence of new generation DNA sequencing 
      technologies used in HLA genotyping, the number of the reported HLA new alleles 
      is dramaticllyincreasing, and more full length sequences of HLA alleles have been 
      reported. The significant association between HLA genes and NPC has been 
      identifiedin a series of studies, including HLA association study, linkage 
      disequilibrium study for microsatellite markers, and genome wide association 
      study. In this review, we summarize association studies between HLA and NPC to 
      evaluate the role of genetic polymorphisms in NPC development and illustrate the 
      new clues of HLA association for deepexploration.
FAU - Tang, Min-Zhong
AU  - Tang MZ
AD  - College of Life Science and Bio-engineering, Beijing University of Technology, 
      Beijing 100124, China. gxtom2000@gmail.com
FAU - Cai, Yong-Lin
AU  - Cai YL
FAU - Zheng, Yu-Ming
AU  - Zheng YM
FAU - Zeng, Yi
AU  - Zeng Y
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - China
TA  - Yi Chuan
JT  - Yi chuan = Hereditas
JID - 9436478
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Carcinoma
MH  - Genetic Association Studies
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/*genetics
EDAT- 2012/12/25 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 0253-9772(2012)12-1505-08 [pii]
AID - 10.3724/sp.j.1005.2012.01505 [doi]
PST - ppublish
SO  - Yi Chuan. 2012 Dec;34(12):1505-12. doi: 10.3724/sp.j.1005.2012.01505.