PMID- 23262235
OWN - NLM
STAT- MEDLINE
DCOM- 20150714
LR  - 20200325
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 232
DP  - 2013 Mar 1
TI  - Repeated paced mating promotes the arrival of more newborn neurons in the main 
      and accessory olfactory bulbs of adult female rats.
PG  - 151-60
LID - S0306-4522(12)01195-5 [pii]
LID - 10.1016/j.neuroscience.2012.12.014 [doi]
AB  - We have previously shown that the first-paced mating encounter increases the 
      number of newborn cells in the granule cell layer (Gra; also known as internal 
      cell layer, ICL) of the accessory olfactory bulb (AOB) in the adult female rat 
      (Corona et al., 2011). In the present study we evaluated if repetition of the 
      stimulus (paced mating) could increase the arrival of more newborn neurons in the 
      olfactory bulb generated during the first session of paced sexual contact. 
      Sexually naive female rats were bilaterally ovariectomized, hormonally 
      supplemented with estradiol (E2) and progesterone (P) and randomly assigned to 
      one of four groups: (1) without sexual contact, (2) one session of paced mating, 
      (3) four sessions of paced mating, and (4) four sessions of non-paced mating. We 
      also included a group of gonadally intact females. On the first day of the 
      experiment, all females were i.p. injected with the marker of DNA synthesis 
      bromodeoxyuridine and were killed 16 days later. Blood was collected at sacrifice 
      to determine the plasma levels of E2 and P. The number of newborn neurons that 
      arrived at the ICL of the AOB and the Gra of the main olfactory bulb (MOB) 
      increased, relative to all other groups, only in the group that repeatedly mated 
      under pacing conditions. No differences were found in E2 and P levels between 
      supplemented groups indicating that our results are not influenced by changes in 
      hormone concentrations. We suggest that repeated paced mating promotes the 
      arrival of more newborn neurons in the AOB and MOB.
CI  - Copyright (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Arzate, D M
AU  - Arzate DM
AD  - Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, 
      Universidad Nacional Autonoma de Mexico, Campus UNAM-Juriquilla, Queretaro, 
      Mexico.
FAU - Portillo, W
AU  - Portillo W
AD  - Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, 
      Universidad Nacional Autonoma de Mexico, Campus UNAM-Juriquilla, Queretaro, 
      Mexico. Electronic address: portillo@unam.mx.
FAU - Corona, R
AU  - Corona R
AD  - Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, 
      Universidad Nacional Autonoma de Mexico, Campus UNAM-Juriquilla, Queretaro, 
      Mexico.
FAU - Paredes, R G
AU  - Paredes RG
AD  - Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, 
      Universidad Nacional Autonoma de Mexico, Campus UNAM-Juriquilla, Queretaro, 
      Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121220
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Antigens, Nuclear)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Rbfox3 protein, rat)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Antigens, Nuclear/metabolism
MH  - Bromodeoxyuridine
MH  - Cell Count
MH  - Estradiol/administration & dosage/metabolism
MH  - Female
MH  - Microscopy, Confocal
MH  - Nerve Tissue Proteins/metabolism
MH  - Neurogenesis/*physiology
MH  - Neurons/cytology/*physiology
MH  - Olfactory Bulb/cytology/*physiology
MH  - Ovariectomy
MH  - Progesterone/administration & dosage/metabolism
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Sexual Behavior, Animal/physiology
EDAT- 2012/12/25 06:00
MHDA- 2015/07/15 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/10/10 00:00 [received]
PHST- 2012/11/27 00:00 [revised]
PHST- 2012/12/09 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - S0306-4522(12)01195-5 [pii]
AID - 10.1016/j.neuroscience.2012.12.014 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Mar 1;232:151-60. doi: 10.1016/j.neuroscience.2012.12.014. 
      Epub 2012 Dec 20.