PMID- 23262494
OWN - NLM
STAT- MEDLINE
DCOM- 20130913
LR  - 20211021
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 102
IP  - 4
DP  - 2013 Apr
TI  - Generic and disease-specific health-related quality of life in patients with 
      chronic systolic heart failure: impact of depression.
PG  - 269-78
LID - 10.1007/s00392-012-0531-4 [doi]
AB  - AIMS: Heart failure is known to profoundly affect health-related quality of life 
      (HRQoL). We aimed to describe both generic and disease-specific HRQoL in a large 
      community-based sample of patients with systolic heart failure (SHF) and to 
      identify important somatic and psychosocial correlates. METHODS AND RESULTS: 
      Seven hundred and two patients, 67 +/- 12 years old, 71 % men, with distributions 
      of New York Heart Association (NYHA) functional classes I/II/III/IV of 2/55/39/4 
      % were included in this cross-sectional analysis. Generic HRQoL was measured with 
      the SF-36 health survey, disease-specific HRQoL with the Kansas City 
      Cardiomyopathy Questionnaire, and depression with the self-reported Patient 
      Health Questionnaire (PHQ-9). Both generic- and disease-specific HRQoL 
      measurements indicated moderate to poor HRQoL. The KCCQ scores demonstrated 
      higher sensitivity to the varying levels of heart failure severity as compared to 
      the SF-36 scores. Patients with either a minor (15 %) or a major depression (24 
      %) reported significantly and substantially lower HRQoL (p < .001) than patients 
      without depression did. In multivariable regression analyses, depression 
      accounted for the largest part of the variance of both generic and specific HRQoL 
      (12 and 36 %, respectively), whereas most biomedical variables had no or only a 
      marginal influence. CONCLUSION: Patients with SHF suffer from severe limitations 
      of HRQoL. Depression was the most important correlate of both generic and 
      disease-specific HRQoL.
FAU - Schowalter, Marion
AU  - Schowalter M
AD  - Department of Medical Psychology, Medical Sociology and Rehabilitation Sciences, 
      University of Wurzburg, Klinikstr. 3, D 97070 Wurzburg, Germany. 
      schowalter@uni-wuerzburg.de
FAU - Gelbrich, Gotz
AU  - Gelbrich G
FAU - Stork, Stefan
AU  - Stork S
FAU - Langguth, Jan-Philip
AU  - Langguth JP
FAU - Morbach, Caroline
AU  - Morbach C
FAU - Ertl, Georg
AU  - Ertl G
FAU - Faller, Hermann
AU  - Faller H
FAU - Angermann, Christiane E
AU  - Angermann CE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121221
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Depression/*epidemiology/physiopathology
MH  - Female
MH  - Heart Failure, Systolic/*physiopathology/psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - *Quality of Life
MH  - Regression Analysis
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
EDAT- 2012/12/25 06:00
MHDA- 2013/09/14 06:00
CRDT- 2012/12/25 06:00
PHST- 2011/08/04 00:00 [received]
PHST- 2012/12/05 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/09/14 06:00 [medline]
AID - 10.1007/s00392-012-0531-4 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2013 Apr;102(4):269-78. doi: 10.1007/s00392-012-0531-4. Epub 
      2012 Dec 21.