PMID- 23262518
OWN - NLM
STAT- MEDLINE
DCOM- 20130416
LR  - 20220409
IS  - 1535-4970 (Electronic)
IS  - 1073-449X (Linking)
VI  - 187
IP  - 4
DP  - 2013 Feb 15
TI  - Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically 
      important difference for death or hospitalization.
PG  - 382-6
LID - 10.1164/rccm.201209-1596OC [doi]
AB  - RATIONALE: Outcomes other than spirometry are required to assess 
      nonbronchodilator therapies for chronic obstructive pulmonary disease. Estimates 
      of the minimal clinically important difference for the 6-minute-walk distance 
      (6MWD) have been derived from narrow cohorts using nonblinded intervention. 
      OBJECTIVES: To determine minimum clinically important difference for change in 
      6MWD over 1 year as a function of mortality and first hospitalization in an 
      observational cohort of patients with COPD. METHODS: Data from the ECLIPSE cohort 
      were used (n = 2,112). Death or first hospitalization were index events; we 
      measured change in 6MWD in the 12-month period before the event and related 
      change in 6MWD to lung function and St. George's Respiratory Questionnaire 
      (health status). MEASUREMENT AND MAIN RESULTS: Of subjects with change in the 
      6MWD data, 94 died, and 323 were hospitalized. 6MWD fell by 29.7 m (SD, 82.9 m) 
      more among those who died than among survivors (P < 0.001). A reduction in 
      distance of more than 30 m conferred a hazard ratio of 1.93 (95% confidence 
      interval, 1.29-2.90; P = 0.001) for death. No significant difference was observed 
      for first hospitalization. Weak relationships only were observed with change in 
      lung function or health status. CONCLUSIONS: A reduction in the 6MWD of 30 m or 
      more is associated with increased risk of death but not hospitalization due to 
      exacerbation in patients with chronic obstructive pulmonary disease and 
      represents a clinically significant minimally important difference.
FAU - Polkey, Michael I
AU  - Polkey MI
AD  - NIHR Respiratory Biomedical Research Unit at the Royal Brompton Hospital and 
      Imperial College London, London, United Kingdom. polkey@rbht.nhs.uk
FAU - Spruit, Martijn A
AU  - Spruit MA
FAU - Edwards, Lisa D
AU  - Edwards LD
FAU - Watkins, Michael L
AU  - Watkins ML
FAU - Pinto-Plata, Victor
AU  - Pinto-Plata V
FAU - Vestbo, Jorgen
AU  - Vestbo J
FAU - Calverley, Peter M A
AU  - Calverley PM
FAU - Tal-Singer, Ruth
AU  - Tal-Singer R
FAU - Agusti, Alvar
AU  - Agusti A
FAU - Bakke, Per S
AU  - Bakke PS
FAU - Coxson, Harvey O
AU  - Coxson HO
FAU - Lomas, David A
AU  - Lomas DA
FAU - MacNee, William
AU  - MacNee W
FAU - Rennard, Stephen
AU  - Rennard S
FAU - Silverman, Edwin K
AU  - Silverman EK
FAU - Miller, Bruce E
AU  - Miller BE
FAU - Crim, Courtney
AU  - Crim C
FAU - Yates, Julie
AU  - Yates J
FAU - Wouters, Emiel F M
AU  - Wouters EF
FAU - Celli, Bartolome
AU  - Celli B
CN  - Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints 
      (ECLIPSE) Study Investigators
LA  - eng
GR  - G0901697/MRC_/Medical Research Council/United Kingdom
GR  - G0901786/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20121221
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
SB  - IM
CIN - Am J Respir Crit Care Med. 2013 Feb 15;187(4):335-6. PMID: 23418323
CIN - Am J Respir Crit Care Med. 2013 Jun 15;187(12):1391-2. PMID: 23767906
CIN - Am J Respir Crit Care Med. 2013 Jun 15;187(12):1392. PMID: 23767907
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Exercise Test/*methods/*statistics & numerical data
MH  - Exercise Tolerance
MH  - Female
MH  - Follow-Up Studies
MH  - Forced Expiratory Volume
MH  - Health Status
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Pulmonary Disease, Chronic Obstructive/diagnosis/*mortality/*physiopathology
MH  - Spirometry
MH  - Surveys and Questionnaires
MH  - Survival Analysis
MH  - Walking
EDAT- 2012/12/25 06:00
MHDA- 2013/04/17 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2013/04/17 06:00 [medline]
AID - rccm.201209-1596OC [pii]
AID - 10.1164/rccm.201209-1596OC [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2013 Feb 15;187(4):382-6. doi: 
      10.1164/rccm.201209-1596OC. Epub 2012 Dec 21.