PMID- 23263551
OWN - NLM
STAT- MEDLINE
DCOM- 20140930
LR  - 20211021
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 33
IP  - 12
DP  - 2013 Dec
TI  - Association of interleukin-18 and systemic lupus erythematosus.
PG  - 3055-7
LID - 10.1007/s00296-012-2623-x [doi]
AB  - Interleukin-18 (IL-18), belongs to the IL-1 cytokine family, has a variety of 
      effects on dendritic cell, T cell, natural killer cell. Previous studies have 
      identified that IL-18 was associated with the pathogenesis of systemic lupus 
      erythematosus (SLE), wherein elevated expression of IL-18 was found in the serum 
      of patients, and IL-18 polymorphisms with susceptibility to SLE were reported, 
      suggesting that IL-18 may be therapeutically relevant to SLE. In this article, we 
      will discuss the role of IL-18 in the pathogenesis of and its therapeutic 
      potential in SLE based on current understandings.
FAU - Xu, Wang-Dong
AU  - Xu WD
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of 
      China.
FAU - Pan, Hai-Feng
AU  - Pan HF
FAU - Ye, Dong-Qing
AU  - Ye DQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121223
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Humans
MH  - Interleukin-18/genetics/*physiology
MH  - Killer Cells, Natural/pathology
MH  - Lupus Erythematosus, Systemic/genetics/pathology/*physiopathology
MH  - Polymorphism, Genetic/genetics
MH  - T-Lymphocytes/pathology
EDAT- 2012/12/25 06:00
MHDA- 2014/10/01 06:00
CRDT- 2012/12/25 06:00
PHST- 2012/06/08 00:00 [received]
PHST- 2012/12/09 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - 10.1007/s00296-012-2623-x [doi]
PST - ppublish
SO  - Rheumatol Int. 2013 Dec;33(12):3055-7. doi: 10.1007/s00296-012-2623-x. Epub 2012 
      Dec 23.