PMID- 23264760
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121225
LR  - 20211021
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 6
DP  - 2012
TI  - Gestational or acute restraint in adulthood reduces levels of 5alpha-reduced 
      testosterone metabolites in the hippocampus and produces behavioral inhibition of 
      adult male rats.
PG  - 40
LID - 10.3389/fncel.2012.00040 [doi]
LID - 40
AB  - Stressors, during early life or adulthood, can alter steroid-sensitive behaviors, 
      such as exploration, anxiety, and/or cognitive processes. We investigated if 
      exposure to acute stressors in adulthood may alter behavioral and neuroendocrine 
      responses of male rats that were exposed to gestational stress or not. We 
      hypothesized that rats exposed to gestational and acute stress may show 
      behavioral inhibition, increased corticosterone, and altered androgen levels in 
      the hippocampus. Subjects were adult, male offspring of rat dams that were 
      restrained daily on gestational days 14-20, or did not experience this 
      manipulation. Immediately before testing, rats were restraint stressed for 20 min 
      or not. During week 1, rats were tested in a battery of tasks, including the open 
      field, elevated plus maze, social interaction, tailflick, pawlick, and defensive 
      burying tasks. During week 2, rats were trained and tested 24 h later in the 
      inhibitory avoidance task. Plasma corticosterone and androgen levels, and 
      hippocampal androgen levels, were measured in all subjects. Gestational and acute 
      restraint stress increased plasma levels of corticosterone, and reduced levels of 
      testosterone's 5alpha-reduced metabolites, dihydrotestosterone (DHT) and 
      3alpha-androstanediol (3alpha-diol), but not the aromatized metabolite, estradiol (E(2)), 
      in plasma or the hippocampus. Gestational and acute restraint stress reduced 
      central entries made in the open field, and latencies to enter the 
      shock-associated side of the inhibitory avoidance chamber during testing. 
      Gestational stress reduced time spent interacting with a conspecific. These data 
      suggest that gestational and acute restraint stress can have actions to produce 
      behavioral inhibition coincident with increased corticosterone and decreased 
      5alpha-reduced androgens of adult male rats. Thus, gestational stress altered neural 
      circuits involved in the neuroendocrine response to acute stress in early 
      adulthood.
FAU - Walf, Alicia A
AU  - Walf AA
AD  - Life Sciences Research, The University at Albany-SUNY Albany, NY, USA.
FAU - Frye, Cheryl A
AU  - Frye CA
LA  - eng
PT  - Journal Article
DEP - 20121218
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC3524518
OTO - NOTNLM
OT  - affect
OT  - androgens
OT  - anxiety
OT  - inhibitory avoidance
OT  - prenatal stress
OT  - testosterone
EDAT- 2012/12/25 06:00
MHDA- 2012/12/25 06:01
PMCR- 2012/01/01
CRDT- 2012/12/25 06:00
PHST- 2012/03/14 00:00 [received]
PHST- 2012/09/12 00:00 [accepted]
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2012/12/25 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2012.00040 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2012 Dec 18;6:40. doi: 10.3389/fncel.2012.00040. eCollection 
      2012.