PMID- 23264884
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2157-7412 (Print)
IS  - 2157-7412 (Electronic)
IS  - 2157-7412 (Linking)
VI  - 3
IP  - 3
DP  - 2012 May 30
TI  - Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry.
PG  - 1000115
AB  - Adverse, unfavourable life conditions, particularly during early life stages and 
      infancy, can lead to epigenetic regulation of genes involved in stress-response, 
      behavioral disinhibition, and cognitive-emotional systems. Over time, the 
      ultimate final outcome can be expressed through behaviors bedeviled by problems 
      with impulse control, such as eating disorders, alcoholism, and indiscriminate 
      social behavior. While many reward gene polymorphisms are involved in impulsive 
      behaviors, a polymorphism by itself may not translate to the development of a 
      particular behavioral disorder unless it is impacted by epigenetic effects. 
      Brain-derived neurotrophic factor (BDNF) affects the development and integrity of 
      the noradrenergic, dopaminergic, serotonergic, glutamatergic, and cholinergic 
      neurotransmitter systems, and plasma levels of the neurotrophin are associated 
      with both cognitive and aggressive impulsiveness. Epigenetic mechanisms 
      associated with a multitude of environmental factors, including premature birth, 
      low birth weight, prenatal tobacco exposure, non-intact family, young maternal 
      age at birth of the target child, paternal history of antisocial behavior, and 
      maternal depression, alter the developmental trajectories for several 
      neuropsychiatric disorders. These mechanisms affect brain development and 
      integrity at several levels that determine structure and function in resolving 
      the final behavioral expressions.
FAU - Archer, Trevor
AU  - Archer T
AD  - Department of Psychology, University of Gothenburg, Box 500, SE-40530 Gothenburg, 
      Sweden.
FAU - Oscar-Berman, Marlene
AU  - Oscar-Berman M
FAU - Blum, Kenneth
AU  - Blum K
FAU - Gold, Mark
AU  - Gold M
LA  - eng
GR  - K05 AA000219/AA/NIAAA NIH HHS/United States
GR  - R01 AA007112/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Genet Syndr Gene Ther
JT  - Journal of genetic syndromes & gene therapy
JID - 101574143
PMC - PMC3526005
MID - NIHMS419174
EDAT- 2012/12/25 06:00
MHDA- 2012/12/25 06:01
PMCR- 2012/12/19
CRDT- 2012/12/25 06:00
PHST- 2012/12/25 06:00 [entrez]
PHST- 2012/12/25 06:00 [pubmed]
PHST- 2012/12/25 06:01 [medline]
PHST- 2012/12/19 00:00 [pmc-release]
AID - 10.4172/2157-7412.1000115 [doi]
PST - ppublish
SO  - J Genet Syndr Gene Ther. 2012 May 30;3(3):1000115. doi: 
      10.4172/2157-7412.1000115.