PMID- 2326505
OWN - NLM
STAT- MEDLINE
DCOM- 19900521
LR  - 20190828
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 28
IP  - 1
DP  - 1990 Mar 27
TI  - Tonic suppression of baroreceptor reflex by endogenous neurotensin in the rat.
PG  - 23-37
AB  - We evaluated the modulatory role of endogenous neurotensin (NT) in baroreceptor 
      reflex (BRR) response in Sprague-Dawley rats anesthetized with pentobarbital 
      sodium. Intracerebroventricular (i.c.v.) administration of NT (15 or 30 nmol) 
      significantly reduced the sensitivity of the BRR response. Blocking the 
      endogenous activity of the tridecapeptide with its specific antagonist, 
      (D-Trp11)-NT (4 or 8 nmol) or antiserum against NT (1:20); or inhibiting the 
      aminopeptidases with bestatin (200 nmol), on the other hand, promoted a 
      potentiation of BRR response. When administered together with bestatin (200 
      nmol), the suppressive effect of NT (15 nmol) on the BRR response was further 
      enhanced, as was the augmentative action of (D-Trp11)-NT (4 nmol). Upon 
      microinjection into the bilateral nucleus tractus solitarius (NTS), NT (600 pmol) 
      and (D-Trp11)-NT (150 pmol) respectively elicited a reduction and enhancement of 
      the BRR response. These results suggest that neurons that contain NT may 
      participate in central cardiovascular regulation by tonically suppressing the 
      BRR, possibly via an action on the NTS where baroreceptor afferents terminate.
FAU - Chen, C T
AU  - Chen CT
AD  - Department of Institute of Pharmacology, National Yang-Ming Medical College, 
      Taipei, Taiwan Republic of China.
FAU - Chan, J Y
AU  - Chan JY
FAU - Barnes, C D
AU  - Barnes CD
FAU - Chan, S H
AU  - Chan SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Immune Sera)
RN  - 1WS297W6MV (Phenylephrine)
RN  - 39379-15-2 (Neurotensin)
RN  - 75644-95-0 (neurotensin, Trp(11)-)
RN  - GMW67QNF9C (Leucine)
RN  - I0J33N5627 (ubenimex)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Heart Rate/drug effects
MH  - Hypertension/chemically induced
MH  - Immune Sera/metabolism
MH  - Injections, Intraventricular
MH  - Kinetics
MH  - Leucine/administration & dosage/*analogs & derivatives/pharmacology
MH  - Male
MH  - Neurotensin/administration & dosage/analogs & derivatives/*pharmacology
MH  - Phenylephrine/adverse effects
MH  - Pressoreceptors/*drug effects/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reflex/*drug effects
MH  - Time Factors
EDAT- 1990/03/27 00:00
MHDA- 1990/03/27 00:01
CRDT- 1990/03/27 00:00
PHST- 1990/03/27 00:00 [pubmed]
PHST- 1990/03/27 00:01 [medline]
PHST- 1990/03/27 00:00 [entrez]
AID - 0167-0115(90)90061-Z [pii]
AID - 10.1016/0167-0115(90)90061-z [doi]
PST - ppublish
SO  - Regul Pept. 1990 Mar 27;28(1):23-37. doi: 10.1016/0167-0115(90)90061-z.