PMID- 23265738
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20141120
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 760
DP  - 2013 Jan 14
TI  - Simultaneous determination of 3-monochloropropane-1,2-diol and acrylamide in food 
      by gas chromatography-triple quadrupole mass spectrometry with coupled column 
      separation.
PG  - 93-9
LID - S0003-2670(12)01713-8 [pii]
LID - 10.1016/j.aca.2012.11.036 [doi]
AB  - Both 3-monochloropropane-1,2-diol (3-MCPD) and acrylamide are contaminants found 
      in heat-processed foods and their related products. A quantitative method was 
      developed for the simultaneous determination of both contaminants in food by gas 
      chromatography-triple quadrupole mass spectrometry (GC-MS/MS). The analytes were 
      purified and extracted by the matrix solid-phase dispersion extraction (MSPDE) 
      technique with Extrelut NT. A coupled column (a 3 m Innowax combined with a 30 m 
      DB-5 ms) was developed to separate both compounds efficiently without 
      derivatization. Triple quadrupole mass spectrometry in multiple reaction 
      monitoring mode (MRM) was applied to suppress matrix interference and obtain good 
      sensitivity in the determination of both analytes. The limit of detection (LOD) 
      in the sample matrix was 5 mug kg(-1) for 3-MCPD or acrylamide. The average 
      recoveries for 3-MCPD and acrylamide in different food matrices were 90.5-107% 
      and 81.9-95.7%, respectively, with the intraday relative standard deviations 
      (RSDs) of 5.6-13.5% and 5.3-13.4%, respectively. The interday RSDs were 6.1-12.6% 
      for 3-MCPD and were 5.0-12.8% for acrylamide. Both contaminants were found in 
      samples of bread, fried chips, fried instant noodles, soy sauce, and instant 
      noodle flavoring. Neither 3-MCPD nor acrylamide was detected in the samples of 
      dairy products (solid or liquid samples) and non-fried instant noodles.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Xu, Xiao-min
AU  - Xu XM
AD  - Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, 
      China.
FAU - He, Hua-li
AU  - He HL
FAU - Zhu, Yan
AU  - Zhu Y
FAU - Feng, Liang
AU  - Feng L
FAU - Ying, Ying
AU  - Ying Y
FAU - Huang, Bai-fen
AU  - Huang BF
FAU - Shen, Hai-tao
AU  - Shen HT
FAU - Han, Jian-long
AU  - Han JL
FAU - Ren, Yi-ping
AU  - Ren YP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121129
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Flavoring Agents)
RN  - 20R035KLCI (Acrylamide)
RN  - 96-24-2 (alpha-Chlorohydrin)
RN  - PDC6A3C0OX (Glycerol)
SB  - IM
MH  - Acrylamide/*analysis/isolation & purification
MH  - Animals
MH  - Cattle
MH  - Dairy Products/analysis
MH  - Fast Foods/analysis
MH  - Flavoring Agents/analysis
MH  - Food Contamination/*analysis
MH  - *Gas Chromatography-Mass Spectrometry
MH  - Glycerol/*analogs & derivatives/analysis/isolation & purification
MH  - Milk/chemistry
MH  - Soy Foods/analysis
MH  - alpha-Chlorohydrin
EDAT- 2012/12/26 06:00
MHDA- 2013/05/29 06:00
CRDT- 2012/12/26 06:00
PHST- 2012/08/16 00:00 [received]
PHST- 2012/11/06 00:00 [revised]
PHST- 2012/11/19 00:00 [accepted]
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
AID - S0003-2670(12)01713-8 [pii]
AID - 10.1016/j.aca.2012.11.036 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2013 Jan 14;760:93-9. doi: 10.1016/j.aca.2012.11.036. Epub 2012 
      Nov 29.