PMID- 23266269
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20201228
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 53
DP  - 2013 Mar
TI  - Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against 
      tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant 
      enzymes.
PG  - 317-24
LID - S0278-6915(12)00889-7 [pii]
LID - 10.1016/j.fct.2012.12.016 [doi]
AB  - Ganodermanondiol, a biologically active compound, was isolated from the Lingzhi 
      mushroom (Ganoderma lucidum). The present study examined the protective effects 
      of ganodermanondiol against tert-butyl hydroperoxide (t-BHP)-induced 
      hepatotoxicity. Ganodermanondiol protected human liver-derived HepG2 cells 
      through nuclear factor-E2-related factor 2 (Nrf2) pathway-dependent heme 
      oxygenase-1 expressions. Moreover, ganodermanondiol increased cellular 
      glutathione levels and the expression of the glutamine-cysteine ligase gene in a 
      dose-dependent manner. Furthermore, ganodermanondiol exposure enhanced the 
      phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) and 
      its upstream kinase activators, LKB1 and Ca(2+)/calmodulin-dependent protein 
      kinase-II (CaMKII). This study indicates that ganodermanondiol exhibits potent 
      cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived 
      HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Li, Bin
AU  - Li B
AD  - Hanbang Body-Fluid Research Center, Wonkwang University, Iksan 570-749, Republic 
      of Korea.
FAU - Lee, Dong-Sung
AU  - Lee DS
FAU - Kang, Yue
AU  - Kang Y
FAU - Yao, Nai-Qi
AU  - Yao NQ
FAU - An, Ren-Bo
AU  - An RB
FAU - Kim, Youn-Chul
AU  - Kim YC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121221
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Antioxidants)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NFE2L2 protein, human)
RN  - 0 (Reactive Oxygen Species)
RN  - 104700-96-1 (ganodermadiol)
RN  - 1J05Z83K3M (Lanosterol)
RN  - 955VYL842B (tert-Butylhydroperoxide)
RN  - EC 1.14.14.18 (Heme Oxygenase-1)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
EIN - Food Chem Toxicol. 2021 Mar;149:111939. PMID: 33358767
MH  - AMP-Activated Protein Kinases/genetics/metabolism
MH  - Agaricales/chemistry
MH  - Antioxidants/*pharmacology
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics/metabolism
MH  - Cytoprotection/drug effects
MH  - Drugs, Chinese Herbal/*chemistry
MH  - Glutathione/metabolism
MH  - Heme Oxygenase-1/genetics/metabolism
MH  - Hep G2 Cells
MH  - Humans
MH  - Lanosterol/*analogs & derivatives/pharmacology
MH  - Liver/*drug effects/enzymology/pathology
MH  - NF-E2-Related Factor 2/*genetics/metabolism
MH  - Phosphorylation
MH  - Reactive Oxygen Species
MH  - Reishi
MH  - Signal Transduction
MH  - tert-Butylhydroperoxide/*toxicity
EDAT- 2012/12/26 06:00
MHDA- 2013/08/27 06:00
CRDT- 2012/12/26 06:00
PHST- 2012/05/18 00:00 [received]
PHST- 2012/12/08 00:00 [revised]
PHST- 2012/12/10 00:00 [accepted]
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - S0278-6915(12)00889-7 [pii]
AID - 10.1016/j.fct.2012.12.016 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2013 Mar;53:317-24. doi: 10.1016/j.fct.2012.12.016. Epub 2012 
      Dec 21.