PMID- 23266412
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20131121
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 90
IP  - 7
DP  - 2013 Feb
TI  - Effects of oil pollution and persistent organic pollutants (POPs) on 
      glycerophospholipids in liver and brain of male Atlantic cod (Gadus morhua).
PG  - 2157-71
LID - S0045-6535(12)01430-0 [pii]
LID - 10.1016/j.chemosphere.2012.11.026 [doi]
AB  - Fish in the North Sea are exposed to relatively high levels of halogenated 
      compounds in addition to the pollutants released by oil production activities. In 
      this study male Atlantic cod (Gadus morhua) were orally exposed to environmental 
      realistic levels (low and high) of weathered crude oil and/or a mixture of POPs 
      for 4weeks. Lipid composition in brain and in liver extracts were analysed in 
      order to assess the effects of the various pollutants on membrane lipid 
      composition and fatty acid profiles. Transcriptional effects in the liver were 
      studied by microarray and quantitative real-time RT-PCR. Chemical analyses 
      confirmed uptake of polychlorinated biphenyls (PCBs) and chlorinated pesticides, 
      polybrominated diphenyl ethers (PBDEs) and perfluorooctanesulfonate (PFOS) in the 
      liver and excretion of metabolites of polyaromatic hydrocarbons (PAHs) in the 
      bile. Treatment with POPs and/or crude oil did not induce significant changes in 
      lipid composition in cod liver. Only a few minor changes were observed in the 
      fatty acid profile of the brain and the lipid classes in the liver. The 
      hypothesis that pollution from oil or POPs at environmental realistic levels 
      alters the lipid composition in marine fish was therefore not confirmed in this 
      study. However, the transcriptional data suggest that the fish were affected by 
      the treatment at the mRNA level. This study suggests that a combination of oil 
      and POPs induce the CYP1a detoxification system and gives an increase in the 
      metabolism and clearing rate of PAHs and POPs, but with no effects on membrane 
      lipids in male Atlantic cod.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Bratberg, Mari
AU  - Bratberg M
AD  - Institute of Marine Research, Bergen, Norway.
FAU - Olsvik, Pal A
AU  - Olsvik PA
FAU - Edvardsen, Rolf B
AU  - Edvardsen RB
FAU - Brekken, Hans Kristian
AU  - Brekken HK
FAU - Vadla, Reidun
AU  - Vadla R
FAU - Meier, Sonnich
AU  - Meier S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121223
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Glycerophospholipids)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Environmental Monitoring
MH  - Gadus morhua/metabolism
MH  - Glycerophospholipids/*metabolism
MH  - Halogenated Diphenyl Ethers/metabolism/toxicity
MH  - Liver/drug effects/*metabolism
MH  - Male
MH  - Petroleum Pollution/statistics & numerical data
MH  - Polychlorinated Biphenyls/metabolism/toxicity
MH  - Water Pollutants, Chemical/metabolism/*toxicity
EDAT- 2012/12/26 06:00
MHDA- 2013/05/17 06:00
CRDT- 2012/12/26 06:00
PHST- 2012/07/24 00:00 [received]
PHST- 2012/11/12 00:00 [revised]
PHST- 2012/11/16 00:00 [accepted]
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
AID - S0045-6535(12)01430-0 [pii]
AID - 10.1016/j.chemosphere.2012.11.026 [doi]
PST - ppublish
SO  - Chemosphere. 2013 Feb;90(7):2157-71. doi: 10.1016/j.chemosphere.2012.11.026. Epub 
      2012 Dec 23.