PMID- 23267031
OWN - NLM
STAT- MEDLINE
DCOM- 20130225
LR  - 20220408
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 80
IP  - 1
DP  - 2013 Jan 1
TI  - Inflammation in complex regional pain syndrome: a systematic review and 
      meta-analysis.
PG  - 106-17
LID - 10.1212/WNL.0b013e31827b1aa1 [doi]
AB  - OBJECTIVES: We conducted a systematic review of the literature with meta-analysis 
      to determine whether complex regional pain syndrome (CRPS) is associated with a 
      specific inflammatory profile and whether this is dependent on the duration of 
      the condition. METHODS: Comprehensive searches of the literature using MEDLINE, 
      Embase, Scopus, Web of Science, and reference lists from published reviews 
      identified articles that measured inflammatory factors in CRPS. Two independent 
      investigators screened titles and abstracts, and performed data extraction and 
      risk of bias assessments. Studies were subgrouped by medium (blood, blister 
      fluid, and CSF) and duration (acute and chronic CRPS). Where possible, 
      meta-analyses of inflammatory factor concentrations were performed and pooled 
      effect sizes were calculated using random-effects models. RESULTS: Twenty-two 
      studies were included in the systematic review and 15 in the meta-analysis. In 
      acute CRPS, the concentrations of interleukin (IL)-8 and soluble tumor necrosis 
      factor receptors I (sTNF-RI) and II (sTNF-RII) were significantly increased in 
      blood. In chronic CRPS, significant increases were found in 1) TNFalpha, bradykinin, 
      sIL-1RI, IL-1Ra, IL-2, sIL-2Ra, IL-4, IL-7, interferon-gamma, monocyte 
      chemoattractant protein-1 (MCP-1), and sRAGE (soluble receptor for advanced 
      glycation end products) in blood; 2) IL-1Ra, MCP-1, MIP-1beta, and IL-6 in blister 
      fluid; and 3) IL-1beta and IL-6 in CSF. Chronic CRPS was also associated with 
      significantly decreased 1) substance P, sE-selectin, sL-selectin, sP-selectin, 
      and sGP130 in blood; and 2) soluble intercellular adhesion molecule-1 (sICAM-1) 
      in CSF. Most studies failed to meet 3 or more of our quality criteria. 
      CONCLUSION: CRPS is associated with the presence of a proinflammatory state in 
      the blood, blister fluid, and CSF. Different inflammatory profiles were found for 
      acute and chronic cases.
FAU - Parkitny, Luke
AU  - Parkitny L
AD  - Neuroscience Research Australia, University of New South Wales, Sydney, 
      Australia.
FAU - McAuley, James H
AU  - McAuley JH
FAU - Di Pietro, Flavia
AU  - Di Pietro F
FAU - Stanton, Tasha R
AU  - Stanton TR
FAU - O'Connell, Neil E
AU  - O'Connell NE
FAU - Marinus, Johan
AU  - Marinus J
FAU - van Hilten, Jacobus J
AU  - van Hilten JJ
FAU - Moseley, G Lorimer
AU  - Moseley GL
LA  - eng
GR  - ID 223354/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Acute Pain/blood/cerebrospinal fluid/diagnosis
MH  - Blister/metabolism
MH  - Chronic Pain/blood/cerebrospinal fluid/diagnosis
MH  - Complex Regional Pain Syndromes/blood/cerebrospinal fluid/*diagnosis
MH  - Humans
MH  - Inflammation Mediators/*metabolism
PMC - PMC3589200
EDAT- 2012/12/26 06:00
MHDA- 2013/02/26 06:00
PMCR- 2013/07/01
CRDT- 2012/12/26 06:00
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2013/02/26 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - 80/1/106 [pii]
AID - WNL204537 [pii]
AID - 10.1212/WNL.0b013e31827b1aa1 [doi]
PST - ppublish
SO  - Neurology. 2013 Jan 1;80(1):106-17. doi: 10.1212/WNL.0b013e31827b1aa1.