PMID- 23267163
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20121225
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 33
IP  - 1
DP  - 2013 Jan
TI  - Long-term results of brachytherapy in early mobile tongue cancer with 10-year 
      minimal follow-up.
PG  - 317-24
AB  - AIM: To retrospectively analyze the long-term toxicities of low-dose-rate 
      interstitial brachytherapy (LDR-BT) with related prognostic factors for patients 
      with early mobile tongue cancer (T1/2N0M0) at a minimum of 10 years' follow-up. 
      PATIENTS AND METHODS: The records of 187 patients treated with LDR-BT between 
      1980 and 2000, out of whom 25 were treated with additional prior external beam 
      irradiation, were reviewed. RESULTS: Overall survival at 15 and 20 years was 
      88.4% and 76.2%, respectively. Complications included tongue ulcer (26%), tongue 
      erosion (3%), tongue atrophy (2%), bone exposure (15%), and osteoradionecrosis 
      (4%). No patient presented xerostomia or taste disorders. Multivariate analysis 
      revealed that tongue ulcer and the use of spacer were significantly associated 
      with bone exposure and osteoradionecrosis. Local recurrence was demonstrated in 
      15 (8%) cases, 93% of which were salvaged by operation. Fifty patients (27%) 
      experienced neck metastasis. CONCLUSION: LDR-BT is an acceptable treatment 
      option, with low rates of long-term toxicity.
FAU - Abdalmear, Mais M
AU  - Abdalmear MM
AD  - Department of Radiology, Graduate School of Medicine, Tokyo Medical and Dental 
      University, 5-45, Yushima 1-chome, Bunkyo-ku, Tokyo, 113-8519, Japan. 
      aamm.mrad@tmd.ac.jp
FAU - Tomita, Makoto
AU  - Tomita M
FAU - Shibuya, Hitoshi
AU  - Shibuya H
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brachytherapy/*adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/etiology/pathology
MH  - Neoplasm Staging
MH  - *Osteoradionecrosis/etiology/pathology
MH  - Radiation Dosage
MH  - Survival Rate
MH  - *Tongue Diseases/complications/pathology
MH  - *Tongue Neoplasms/complications/mortality/pathology/radiotherapy
EDAT- 2012/12/26 06:00
MHDA- 2013/06/01 06:00
CRDT- 2012/12/26 06:00
PHST- 2012/12/26 06:00 [entrez]
PHST- 2012/12/26 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - 33/1/317 [pii]
PST - ppublish
SO  - Anticancer Res. 2013 Jan;33(1):317-24.