PMID- 23267878
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20201216
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 39
IP  - 12
DP  - 2012 Nov
TI  - [Clinical study of Peptide-cocktail vaccination with tegafur-uracil/leucovorin 
      for advanced colorectal cancer].
PG  - 1760-2
AB  - cDNA microarray technology coupled with laser microdissection has been used to 
      identify human leukocyte antigen(HLA)-A24-restricted epitope peptides as 
      potential targets for cancer vaccination in colorectal cancer patients. These 
      antigenic peptides were derived from 2 different testis cancer antigens, ring 
      finger protein 43(RNF43) and translocase of outer mitochondrial membrane 
      34(TOMM34). We conducted a clinical trial of vaccines against colorectal cancer 
      specific peptides(RNF43 and TOMM34) with tegafur-uracil/Leucovorin( UFT/LV) for 
      the treatment of advanced or recurrent colorectal cancer. The vaccinations were 
      well tolerated without any adverse events. The highest long-term survival was 
      observed in the group showing cytolytic T-lymphocyte (CTL) responses against both 
      RNF43 and TOMM34, followed by the group showing CTL responses against only RNF43 
      or only TOMM34. A new study has been planned in order to obtain more 
      immunological responses, and we have started a clinical trial of vaccines against 
      multiple peptides[RNF43, TOMM34, forkhead box protein M1(FOXM1), maternal 
      embryonic leucine zipper kinase(MELK), holliday junction recognition 
      protein(HJURP), vascular endothelial growth factor receptor (VEGFR)1, and 
      VEGFR2]by using UFT/LV for the treatment of advanced or recurrent colorectal 
      cancer.
FAU - Sugiura, Fumiaki
AU  - Sugiura F
AD  - Dept. of Surgery, Kinki University, School of Medicine, Japan.
FAU - Inoue, Keisuke
AU  - Inoue K
FAU - Okuno, Kiyotaka
AU  - Okuno K
FAU - Sukegawa, Yasushi
AU  - Sukegawa Y
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0 (Cancer Vaccines)
RN  - 0 (Vaccines, Subunit)
RN  - 1548R74NSZ (Tegafur)
RN  - 56HH86ZVCT (Uracil)
RN  - Q573I9DVLP (Leucovorin)
SB  - IM
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
MH  - Cancer Vaccines/administration & dosage
MH  - Colorectal Neoplasms/*drug therapy
MH  - Female
MH  - Humans
MH  - Leucovorin/administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Tegafur/administration & dosage
MH  - Uracil/administration & dosage
MH  - Vaccines, Subunit/administration & dosage
EDAT- 2012/12/27 06:00
MHDA- 2013/04/10 06:00
CRDT- 2012/12/27 06:00
PHST- 2012/12/27 06:00 [entrez]
PHST- 2012/12/27 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 2012 Nov;39(12):1760-2.