PMID- 23268155
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20121226
IS  - 2737-5935 (Electronic)
IS  - 0037-5675 (Linking)
VI  - 53
IP  - 12
DP  - 2012 Dec
TI  - Prevalence of glucose intolerance, and associated antenatal and historical risk 
      factors among Malaysian women with a history of gestational diabetes mellitus.
PG  - 814-20
AB  - INTRODUCTION: Women with previous gestational diabetes mellitus (PGDM) are at 
      increased risk of future glucose intolerance. This study aimed to determine the 
      prevalence of prediabetes and type 2 diabetes mellitus (T2DM), and the associated 
      antenatal and historical risk factors among women with PGDM. METHODS: This was a 
      cross-sectional study conducted at University Malaya Medical Centre, Kuala 
      Lumpur, Malaysia. A 75-g 2-hour oral glucose tolerance test was performed in a 
      cohort of multiethnic women with PGDM. Body mass index, waist and hip 
      circumferences, fasting lipid profile and blood pressure were obtained. Data 
      pertaining to the index gestational diabetes mellitus (GDM) were obtained from 
      medical records and interviews. RESULTS: 448 women were enrolled in the study. 
      The prevalence of prediabetes and T2DM was 26.2% and 35.5%, respectively. On 
      multinomial logistic regression analysis, fasting plasma glucose at diagnosis of 
      index GDM and duration lapse after index GDM were shown to be significantly 
      higher in women with isolated impaired fasting glucose (IFG), combined 
      IFG/impaired glucose tolerance and T2DM, as compared to women with normal glucose 
      tolerance (p < 0.05). 2-hour plasma glucose at diagnosis of index GDM was 
      significantly higher only in women who progressed to T2DM when compared to those 
      that remained normal glucose tolerant (p < 0.05). CONCLUSION: In this study, 
      duration lapse after index GDM, fasting plasma glucose and 2-hour plasma glucose 
      at diagnosis of index GDM were important risk factors for early identification of 
      women at high risk for future glucose intolerance. These may be useful for 
      developing potential preventive strategies.
FAU - Chew, Wai Fong
AU  - Chew WF
AD  - Department of Pre-clinical Sciences, Faculty of Medicine and Health Sciences, 
      Universiti Tunku Abdul Rahman, Selangor, Malaysia.
FAU - Rokiah, Pendek
AU  - Rokiah P
FAU - Chan, Siew Pheng
AU  - Chan SP
FAU - Chee, Winnie Siew Swee
AU  - Chee WS
FAU - Lee, Lai Fun
AU  - Lee LF
FAU - Chan, Yoke Mun
AU  - Chan YM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Singapore Med J
JT  - Singapore medical journal
JID - 0404516
RN  - 0 (Blood Glucose)
SB  - IM
EIN - Singapore Med J. 2013 Jan;54(1):58
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Diabetes, Gestational/*blood
MH  - Female
MH  - Glucose Intolerance/blood/*epidemiology/etiology
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Malaysia/epidemiology
MH  - Postpartum Period/*blood
MH  - Prediabetic State/*epidemiology/etiology
MH  - Pregnancy
MH  - Prevalence
MH  - Risk Factors
EDAT- 2012/12/27 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/12/27 06:00
PHST- 2012/12/27 06:00 [entrez]
PHST- 2012/12/27 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
PST - ppublish
SO  - Singapore Med J. 2012 Dec;53(12):814-20.