PMID- 23269521
OWN - NLM
STAT- MEDLINE
DCOM- 20130819
LR  - 20211021
IS  - 1573-7039 (Electronic)
IS  - 1083-3021 (Print)
IS  - 1083-3021 (Linking)
VI  - 18
IP  - 1
DP  - 2013 Mar
TI  - Impaired mitochondrial metabolism and mammary carcinogenesis.
PG  - 75-87
LID - 10.1007/s10911-012-9271-3 [doi]
AB  - Mitochondrial oxidative metabolism plays a key role in meeting energetic demands 
      of cells by oxidative phosphorylation (OxPhos). Here, we have briefly discussed 
      (a) the dynamic relationship that exists among glycolysis, the tricarboxylic acid 
      (TCA) cycle, and OxPhos; (b) the evidence of impaired OxPhos (i.e. mitochondrial 
      dysfunction) in breast cancer; (c) the mechanisms by which mitochondrial 
      dysfunction can predispose to cancer; and (d) the effects of host and 
      environmental factors that can negatively affect mitochondrial function. We 
      propose that impaired OxPhos could increase susceptibility to breast cancer via 
      suppression of the p53 pathway, which plays a critical role in preventing 
      tumorigenesis. OxPhos is sensitive to a large number of factors intrinsic to the 
      host (e.g. inflammation) as well as environmental exposures (e.g. pesticides, 
      herbicides and other compounds). Polymorphisms in over 143 genes can also 
      influence the OxPhos system. Therefore, declining mitochondrial oxidative 
      metabolism with age due to host and environmental exposures could be a common 
      mechanism predisposing to cancer.
FAU - Yadava, Nagendra
AU  - Yadava N
AD  - Pioneer Valley Life Sciences Institute, Springfield, MA 01107, USA. 
      Nagendra.Yadava@baystatehealth.org
FAU - Schneider, Sallie S
AU  - Schneider SS
FAU - Jerry, D Joseph
AU  - Jerry DJ
FAU - Kim, Chul
AU  - Kim C
LA  - eng
GR  - R21 NS057224/NS/NINDS NIH HHS/United States
GR  - R21NS057224-01A2/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121227
PL  - United States
TA  - J Mammary Gland Biol Neoplasia
JT  - Journal of mammary gland biology and neoplasia
JID - 9601804
RN  - 0 (Carcinogens, Environmental)
SB  - IM
MH  - Animals
MH  - Breast Neoplasms/chemically induced/*metabolism
MH  - Carcinogens, Environmental/toxicity
MH  - Disease Susceptibility/chemically induced/metabolism
MH  - Environmental Exposure/adverse effects
MH  - Female
MH  - Humans
MH  - Mammary Glands, Animal/drug effects/metabolism
MH  - Mammary Glands, Human/drug effects/*metabolism
MH  - Mitochondria/drug effects/*metabolism
MH  - Oxidative Phosphorylation/drug effects
PMC - PMC3581737
MID - NIHMS431638
EDAT- 2012/12/28 06:00
MHDA- 2013/08/21 06:00
PMCR- 2014/03/01
CRDT- 2012/12/28 06:00
PHST- 2012/10/01 00:00 [received]
PHST- 2012/12/13 00:00 [accepted]
PHST- 2012/12/28 06:00 [entrez]
PHST- 2012/12/28 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - 10.1007/s10911-012-9271-3 [doi]
PST - ppublish
SO  - J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):75-87. doi: 
      10.1007/s10911-012-9271-3. Epub 2012 Dec 27.