PMID- 23269580
OWN - NLM
STAT- MEDLINE
DCOM- 20130725
LR  - 20211021
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 30
IP  - 1
DP  - 2013 Mar
TI  - Prognostic value of interleukin-6 and interleukin-8 in laryngeal squamous cell 
      cancer.
PG  - 333
LID - 10.1007/s12032-012-0333-6 [doi]
AB  - The aim of this study was to evaluate serum levels of interleukin-6 (IL-6) and 
      interleukin-8 (IL-8) as prognostic variables in patients with laryngeal squamous 
      cell cancer. A total of 92 patients with primary diagnosis of laryngeal squamous 
      cell cancer (LSCC), treated between 2003 and 2005, were included in this 
      evaluation. Preoperative serum levels of IL-6 and IL-8 were measured by 
      enzyme-linked immunosorbent assay methods. Results were compared according to 
      clinical and pathological date criteria. Serum IL-6 and IL-8 levels were 
      significantly higher in patients with LSCC compared to healthy controls (P < 
      0.0001). Serum IL-6 level was associated with lymph node metastasis (P < 0.001), 
      T classification (P < 0.001) and clinical stage (P = 0.001). Multivariate 
      analysis indicated that serum IL-6 was an independent predictor of LSCC-specific 
      progression-free survival (P = 0.049) and overall survival (P = 0.040). Higher 
      serum IL-6 level (IL-6 > 9.7 pg/ml) was associated with a shortened overall 
      survival and progression-free survival (P < 0.05). Our data indicate that serum 
      IL-6 is associated with the development and progression of LSCC. Serum IL-6 may 
      serve as an independent prognostic marker for LSCC patients.
FAU - Hao, Wenwei
AU  - Hao W
AD  - Department of Otolaryngological, Tianjin Medical University General Hospital, 
      Tianjin 300052, People's Republic of China.
FAU - Zhu, Yongping
AU  - Zhu Y
FAU - Zhou, Huifang
AU  - Zhou H
LA  - eng
PT  - Journal Article
DEP - 20121227
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Biomarkers, Tumor/*blood
MH  - Disease-Free Survival
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Interleukin-8/*blood
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*blood/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Neoplasms, Squamous Cell/*blood/mortality/pathology
MH  - Prognosis
MH  - Proportional Hazards Models
EDAT- 2012/12/28 06:00
MHDA- 2013/07/26 06:00
CRDT- 2012/12/28 06:00
PHST- 2012/09/20 00:00 [received]
PHST- 2012/09/26 00:00 [accepted]
PHST- 2012/12/28 06:00 [entrez]
PHST- 2012/12/28 06:00 [pubmed]
PHST- 2013/07/26 06:00 [medline]
AID - 10.1007/s12032-012-0333-6 [doi]
PST - ppublish
SO  - Med Oncol. 2013 Mar;30(1):333. doi: 10.1007/s12032-012-0333-6. Epub 2012 Dec 27.