PMID- 23269899
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121228
LR  - 20240321
IS  - 1226-4512 (Print)
IS  - 2093-3827 (Electronic)
IS  - 1226-4512 (Linking)
VI  - 16
IP  - 6
DP  - 2012 Dec
TI  - Effect of berberine on depression- and anxiety-like behaviors and activation of 
      the noradrenergic system induced by development of morphine dependence in rats.
PG  - 379-86
LID - 10.4196/kjpp.2012.16.6.379 [doi]
AB  - The purpose of this study was to evaluate whether berberine (BER) administration 
      could attenuate depression- and anxiety-like behaviors and increase 
      corticotrophin-releasing factor (CRF) and tyrosine hydroxylase (TH) expression 
      following chronic morphine withdrawal in rats. Male rats were exposed to chronic, 
      intermittent, escalating morphine (10~50 mg/kg) for 10 days. After the last 
      morphine injection, depression- and anxiety-like beahvior associated with 
      morphine discontinuation persisted for at least three days during withdrawal 
      without any change in ambulatory activity. Daily BER administration significantly 
      decreased immobility in the forced swimming test and increased open-arm 
      exploration in the elevated plus maze test. BER administration also significantly 
      blocked the increase in hypothalamic CRF expression and TH expression in the 
      locus coeruleus (LC) and the decrease in hippocampal brain-derived neurotrophic 
      factor (BDNF) mRNA expression. Taken together, these findings demonstrated that 
      BER administration significantly reduced morphine withdrawal-associated behaviors 
      following discontinuation of repeated morphine administration in rats, possibly 
      through modulation of hypothalamic CRF and the central noradrenergic system. BER 
      may be a useful agent for treating or alleviating complex withdrawal symptoms and 
      preventing morphine use relapses.
FAU - Lee, Bombi
AU  - Lee B
AD  - Acupuncture and Meridian Science Research Center, College of Oriental Medicine, 
      Kyung Hee University, Seoul 130-701, Korea.
FAU - Sur, Bongjun
AU  - Sur B
FAU - Yeom, Mijung
AU  - Yeom M
FAU - Shim, Insop
AU  - Shim I
FAU - Lee, Hyejung
AU  - Lee H
FAU - Hahm, Dae-Hyun
AU  - Hahm DH
LA  - eng
PT  - Journal Article
DEP - 20121210
PL  - Korea (South)
TA  - Korean J Physiol Pharmacol
JT  - The Korean journal of physiology & pharmacology : official journal of the Korean 
      Physiological Society and the Korean Society of Pharmacology
JID - 9709505
PMC - PMC3526741
OTO - NOTNLM
OT  - Berberine
OT  - Corticotrophin-releasing factor
OT  - Depression
OT  - Morphine
OT  - Tyrosine hydroxylase
EDAT- 2012/12/28 06:00
MHDA- 2012/12/28 06:01
PMCR- 2012/12/01
CRDT- 2012/12/28 06:00
PHST- 2012/04/09 00:00 [received]
PHST- 2012/11/05 00:00 [revised]
PHST- 2012/11/10 00:00 [accepted]
PHST- 2012/12/28 06:00 [entrez]
PHST- 2012/12/28 06:00 [pubmed]
PHST- 2012/12/28 06:01 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - 10.4196/kjpp.2012.16.6.379 [doi]
PST - ppublish
SO  - Korean J Physiol Pharmacol. 2012 Dec;16(6):379-86. doi: 
      10.4196/kjpp.2012.16.6.379. Epub 2012 Dec 10.