PMID- 23270505
OWN - NLM
STAT- MEDLINE
DCOM- 20141024
LR  - 20221207
IS  - 1563-5279 (Electronic)
IS  - 0020-7454 (Linking)
VI  - 123
IP  - 6
DP  - 2013 Jun
TI  - Val66Met polymorphism and BDNF levels in Alzheimer's disease patients in North 
      Indian population.
PG  - 409-16
LID - 10.3109/00207454.2012.762515 [doi]
AB  - Analysis of serum brain-derived neurotrophic factor (BDNF) levels in Alzheimer's 
      disease (AD), amnestic mild cognitive impairment (aMCI) and controls with BDNF 
      gene polymorphism and cognitive function were investigated. The study recruited 
      63 AD patients, 15 aMCI and 63 age- and sex-matched healthy controls from All 
      India Institute of Medical Sciences, New Delhi, India. Patients with AD (12268.3 
      +/- 7099.9 pg BDNF/ml) and aMCI (10780 +/- 4184.2 pg BDNF/ml) had higher serum levels 
      than had the controls (9362.833 +/- 5883.32 pg BDNF/ml). Significant difference in 
      BDNF levels was not found between the three groups. No significant difference was 
      obtained between BDNF genotype and allele distribution between AD patients, aMCI 
      versus controls; genotypic frequency: Chi-square = 3.21; p-value = 0.20 and 
      allelic frequency: Chi-square = 0.412, p-value = 0.521, df = 1 (AD vs controls); 
      Chi-square = 1.63, p-value = 0.201, df = 1 (aMCI vs controls). In conclusion, 
      val66met polymorphism and BDNF serum level between the three groups and genotype 
      did not significantly affect the serum BDNF level or age, Mini-Mental State 
      Examination score in AD and aMCI. Further studies are necessary to elucidate the 
      kinetics and the potential role of serum BDNF as a marker of disease progression 
      in AD patients.
FAU - Sonali, Nirmal
AU  - Sonali N
AD  - Department of Neurobiochemistry, All India Institute of Medical Sciences, New 
      Delhi, India.
FAU - Tripathi, Manjari
AU  - Tripathi M
FAU - Sagar, Rajesh
AU  - Sagar R
FAU - Vivekanandhan, Subbiah
AU  - Vivekanandhan S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130204
PL  - England
TA  - Int J Neurosci
JT  - The International journal of neuroscience
JID - 0270707
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Alzheimer Disease/*blood/*genetics
MH  - Amnesia/blood/genetics
MH  - Brain-Derived Neurotrophic Factor/*blood/*genetics
MH  - Case-Control Studies
MH  - Cognitive Dysfunction/blood/genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - India
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - White People/*genetics
EDAT- 2012/12/29 06:00
MHDA- 2014/10/25 06:00
CRDT- 2012/12/29 06:00
PHST- 2012/12/29 06:00 [entrez]
PHST- 2012/12/29 06:00 [pubmed]
PHST- 2014/10/25 06:00 [medline]
AID - 10.3109/00207454.2012.762515 [doi]
PST - ppublish
SO  - Int J Neurosci. 2013 Jun;123(6):409-16. doi: 10.3109/00207454.2012.762515. Epub 
      2013 Feb 4.