PMID- 23270976
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 251
DP  - 2013 Aug 15
TI  - Reduced social interaction, behavioural flexibility and BDNF signalling in the 
      BTBR T+ tf/J strain, a mouse model of autism.
PG  - 35-40
LID - S0166-4328(12)00810-8 [pii]
LID - 10.1016/j.bbr.2012.12.028 [doi]
AB  - Autism is a neurodevelopmental disorder characterized by social and communication 
      impairments and repetitive behaviours. The inbred BTBR T+ tf/J (BTBR) strain, a 
      putative mouse model of autism, exhibits lower social interactions, higher 
      repetitive self-grooming levels and unusual pattern of vocalizations as compared 
      to C57BL/6J strain. First aim of the present study was to evaluate at adolescence 
      (postnatal days 30-35) male BTBR and C57BL/6J performances in two different tasks 
      involving either investigation of social cues (same strain partners) or non 
      social ones (inanimate objects). In the social interaction test, BTBR mice showed 
      a reduction of investigation of the social partner, due to a selective reduction 
      of head sniffing, associated with a decrease in ultrasonic vocalizations. By 
      contrast, no strain differences were detected in object investigations. Second 
      aim of the study was to evaluate adult male BTBR and C57BL/6J performances in a 
      fear conditioning task. Strain differences were evident during contextual retest: 
      these strain differences primarily suggested a lack of behavioural flexibility in 
      BTBR mice (i.e., realizing the occurrence of changes in the experimental 
      paradigm). Subsequent electrophysiological analysis in hippocampal slices from 
      adult BTBR and C57BL/6J mice revealed a significant reduction of Brain Derived 
      Neurotrophic Factor (BDNF)-induced potentiation of synaptic transmission in BTBR 
      mice. BDNF and tyrosine kinase B (TrkB) protein levels measured in the 
      hippocampal region were also lower in BTBR as compared to C57BL/6J mice. These 
      data confirm the presence of low levels of direct interaction with social stimuli 
      in BTBR mice at adolescence, in the absence of any strain difference as for 
      investigation of physical objects. At adulthood in BTBR mice clear signs of 
      behavioural inflexibility were evident whereas both biochemical and 
      electrophysiological data point to decreased BDNF signalling (likely due to a 
      reduction in TrkB levels) in the hippocampus of this mouse strain.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Scattoni, M L
AU  - Scattoni ML
AD  - Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale 
      Regina Elena, 299 I-00161 Rome, Italy.
FAU - Martire, A
AU  - Martire A
FAU - Cartocci, G
AU  - Cartocci G
FAU - Ferrante, A
AU  - Ferrante A
FAU - Ricceri, L
AU  - Ricceri L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121225
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Autistic Disorder/metabolism/*psychology
MH  - Behavior, Animal/*physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Conditioning, Psychological/physiology
MH  - Disease Models, Animal
MH  - Fear/psychology
MH  - Grooming/physiology
MH  - Hippocampus/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Receptor, trkB/metabolism
MH  - Signal Transduction/*physiology
MH  - *Social Behavior
MH  - Vocalization, Animal/*physiology
OTO - NOTNLM
OT  - 5HTT
OT  - ACSF
OT  - ASD
OT  - B6
OT  - BDNF-induced potentiation
OT  - BTBR
OT  - BTBR T+tf/J
OT  - C57BL6/j
OT  - Object exploration
OT  - PND
OT  - TrkB
OT  - Ultrasonic vocalizations
OT  - artificial cerebrospinal fluid
OT  - autism spectrum disorders
OT  - postnatal day
OT  - serotonin transporter
OT  - trkB
OT  - tyrosine receptor kinase B
EDAT- 2012/12/29 06:00
MHDA- 2013/10/22 06:00
CRDT- 2012/12/29 06:00
PHST- 2012/08/01 00:00 [received]
PHST- 2012/12/07 00:00 [revised]
PHST- 2012/12/17 00:00 [accepted]
PHST- 2012/12/29 06:00 [entrez]
PHST- 2012/12/29 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - S0166-4328(12)00810-8 [pii]
AID - 10.1016/j.bbr.2012.12.028 [doi]
PST - ppublish
SO  - Behav Brain Res. 2013 Aug 15;251:35-40. doi: 10.1016/j.bbr.2012.12.028. Epub 2012 
      Dec 25.