PMID- 23272694
OWN - NLM
STAT- MEDLINE
DCOM- 20130925
LR  - 20220618
IS  - 1944-7930 (Electronic)
IS  - 1539-6509 (Linking)
VI  - 14
IP  - 79
DP  - 2012 Dec
TI  - Infectious pathogens and hematologic malignancy.
PG  - 421-33
AB  - Infectious pathogens have been linked to the genesis of malignancy in a variety 
      of different settings. Initial studies in virology led to the important discovery 
      of key genetic alterations underlying common malignancies, and further, lent 
      support to the notion that malignancy can be promoted by the process of viral 
      infection and cellular transformation. In this review, we summarize a series of 
      hematologic malignancies with derivations from and associations with infectious 
      organisms. Among these are a variety of lymphomas, including Hodgkin's lymphoma 
      (Hodgkin's disease), Burkitt lymphoma, and a host of other non-Hodgkin's 
      lymphomas. Through innovative and ground-breaking studies, some of these 
      malignancies have been directly linked to viral infection, such as the 
      Epstein-Barr virus (EBV), while others have been merely associated with infection 
      through epidemiologic studies and case-reports. Some malignancies have been 
      demonstrated to be caused by viral infection, such as adult T-cell leukemia and 
      lymphoma (ATLL), which is caused by the human T cell lymphotropic virus type I 
      (HTLV-I), in certain endemic area. In the future, additional malignant states may 
      be found to be associated with infectious etiology, which could allow for novel 
      approaches to prevention and treatment.
FAU - Sadrzadeh, Hossein
AU  - Sadrzadeh H
AD  - Center for Leukemia and the Bone Marrow Transplant Unit, Division of 
      Hematology/Oncology, Massachusetts General Hospital, Harvard Medical School, 
      Boston, Massachusetts 02114, USA.
FAU - Abtahi, Seyed M
AU  - Abtahi SM
FAU - Fathi, Amir T
AU  - Fathi AT
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Discov Med
JT  - Discovery medicine
JID - 101250006
SB  - IM
CIN - Int Urol Nephrol. 2022 Jul;54(7):1775-1776. PMID: 34813025
MH  - Communicable Diseases/*complications/microbiology/virology
MH  - Disease Progression
MH  - Hematologic Neoplasms/complications/*microbiology/*virology
MH  - Humans
EDAT- 2013/01/01 06:00
MHDA- 2013/09/26 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
PST - ppublish
SO  - Discov Med. 2012 Dec;14(79):421-33.