PMID- 23273588
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20121231
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 19
IP  - 1
DP  - 2013 Jan
TI  - A randomized controlled pilot study of outcomes of strict allowance of fluid 
      therapy in hyponatremic heart failure (SALT-HF).
PG  - 1-9
LID - S1071-9164(12)01362-0 [pii]
LID - 10.1016/j.cardfail.2012.11.007 [doi]
AB  - BACKGROUND: Currently, fluid restriction recommendations in heart failure (HF) 
      are based on expert opinion. After implementing a 1,000-mL/d fluid restriction 
      for 60 days after discharge, outcomes were examined. METHODS AND RESULTS: In a 
      randomized controlled design, hyponatremic patients (serum sodium </=137 mg/dL) 
      received usual care (UC; n = 26) or 1,000 mL/d fluid restriction (n = 20) at 
      discharge. Quality of life (QoL), thirst, difficulty following fluid 
      recommendations, adherence to fluid restriction, HF emergency care, HF 
      rehospitalization, and all-cause death were examined. Mean age was 62.8 +/- 12.8 
      years; 46% were white. There were no differences by group in baseline 
      demographics, comorbidities, and QoL, except that more UC patients had New York 
      Heart Association (NYHA) functional class III/IV status (P = .019). Median 
      [interquartile range] QoL scores were better in the 1,000 mL/d group for symptom 
      burden (83.3 [68.8-91.7] vs 50 [29.2-79.2]; P = .018), total symptoms (77.1 
      [58.1-91.7] vs 54.2 [30.2-73.9]; P = .022), overall QoL summary (72.6 [52.2-86.3] 
      vs 51.0 [37.7-68.5]; P = .038), and clinical QoL summary (75.5 [57.8-92.9] vs 
      59.1 [35.7-77.3]; P = .039). There were no group differences in thirst, 
      difficulty adhering to fluid recommendations, adherence to fluid restriction, or 
      health care consumption. CONCLUSIONS: The 1,000 mL/d fluid restriction led to 
      improved QoL at 60 days after discharge. Future research in a larger more 
      heterogeneous sample is needed.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Albert, Nancy M
AU  - Albert NM
AD  - Nursing Research and Innovation, Nursing Institute, Cleveland Clinic Foundation, 
      Cleveland, Ohio, USA. albertn@ccf.org
FAU - Nutter, Benjamin
AU  - Nutter B
FAU - Forney, Jennifer
AU  - Forney J
FAU - Slifcak, Ellen
AU  - Slifcak E
FAU - Tang, W H Wilson
AU  - Tang WH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Analysis of Variance
MH  - *Cause of Death
MH  - Cross-Over Studies
MH  - Female
MH  - Fluid Therapy/*methods
MH  - Follow-Up Studies
MH  - Heart Failure/diagnosis/*mortality/*therapy
MH  - Humans
MH  - Hyponatremia/diagnosis/mortality/*therapy
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Patient Readmission/statistics & numerical data
MH  - Pilot Projects
MH  - *Quality of Life
MH  - Reference Values
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Sex Factors
MH  - Single-Blind Method
MH  - Statistics, Nonparametric
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2013/01/01 06:00
MHDA- 2013/06/01 06:00
CRDT- 2013/01/01 06:00
PHST- 2012/08/13 00:00 [received]
PHST- 2012/11/12 00:00 [revised]
PHST- 2012/11/13 00:00 [accepted]
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
AID - S1071-9164(12)01362-0 [pii]
AID - 10.1016/j.cardfail.2012.11.007 [doi]
PST - ppublish
SO  - J Card Fail. 2013 Jan;19(1):1-9. doi: 10.1016/j.cardfail.2012.11.007.