PMID- 23274780
OWN - NLM
STAT- MEDLINE
DCOM- 20130730
LR  - 20180126
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 110 Suppl 1
DP  - 2013 Jun
TI  - Is postoperative cognitive dysfunction a risk factor for dementia? A cohort 
      follow-up study.
PG  - i92-7
LID - 10.1093/bja/aes466 [doi]
AB  - BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common complication 
      in elderly patients after major surgery. An association between POCD and the 
      development of dementia has been suspected. In this study, we assessed if POCD 
      was a risk factor for the occurrence of dementia. METHODS: Danish patients 
      enrolled between November 1994 and October 2000 in the two International Studies 
      of Postoperative Cognitive Dysfunction (ISPOCD 1 and 2) were followed until July 
      1, 2011. Cognitive performance was assessed at three time points: before 
      operation, at 1 week, and 3 months after surgery, using a neuropsychological test 
      battery. The time of (first) occurrence of dementia after surgery was assessed 
      using the National Patient Register and the Psychiatric Central Research 
      Register. Recorded dementia diagnoses (ICD-8 and ICD-10) were: Alzheimer's 
      disease, vascular dementia, frontotemporal dementia, or dementia without 
      specification. The risk of dementia according to POCD was assessed in the Cox 
      regression models. RESULTS: A total of 686 patients with a median age of 67 
      [inter-quartile range (IQR) 61-74] yr were followed for a median of 11.1 (IQR 
      5.2-12.6) yr. Only 32 patients developed dementia during follow-up. The hazard 
      ratio (95% CI) for any dementia diagnoses in patients with POCD at 1 week (n=118) 
      and POCD at 3 months (n=57) after surgery compared with those without POCD was 
      1.16 (0.48-2.78), P=0.74, and 1.50 (0.51-4.44); P=0.47, respectively. 
      CONCLUSIONS: POCD was not significantly associated with registered dementia over 
      a median follow-up of 11 yr.
FAU - Steinmetz, J
AU  - Steinmetz J
AD  - Department of Anaesthesia, Center of Head and Orthopaedics, HOC 4231, Copenhagen 
      University Hospital, Rigshospitalet, DK-2100 Copenhagen, Denmark. 
      jacobsteinmetz@dadlnet.dk
FAU - Siersma, V
AU  - Siersma V
FAU - Kessing, L V
AU  - Kessing LV
FAU - Rasmussen, L S
AU  - Rasmussen LS
CN  - ISPOCD Group
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20121228
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cognition Disorders/diagnosis/epidemiology/etiology/*psychology
MH  - Dementia/epidemiology/*etiology
MH  - Denmark/epidemiology
MH  - Depression/epidemiology/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Postoperative Complications/diagnosis/epidemiology/*psychology
MH  - Postoperative Period
MH  - Risk Factors
OTO - NOTNLM
OT  - dementia
OT  - postoperative cognitive dysfunction
OT  - postoperative complications
EDAT- 2013/01/01 06:00
MHDA- 2013/07/31 06:00
CRDT- 2013/01/01 06:00
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - S0007-0912(17)32653-3 [pii]
AID - 10.1093/bja/aes466 [doi]
PST - ppublish
SO  - Br J Anaesth. 2013 Jun;110 Suppl 1:i92-7. doi: 10.1093/bja/aes466. Epub 2012 Dec 
      28.