PMID- 23275201
OWN - NLM
STAT- MEDLINE
DCOM- 20130913
LR  - 20211021
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 40
IP  - 5
DP  - 2013 May
TI  - Modulation of hsa-miR-26b levels following adipokine stimulation.
PG  - 3577-82
LID - 10.1007/s11033-012-2431-0 [doi]
AB  - MicroRNAs (miRNAs) are short non-coding RNAs that are involved in 
      post-transcriptional regulation of gene expression. Hsa-miR-26b is an intronic 
      miRNA located in the intron of CTDSP1 (carboxy-terminal domain, RNA polymerase 
      II, polypeptide A, small phosphatase 1). In the present study, the expression of 
      hsa-miR-26b was examined during human preadipocyte differentiation. 15 days after 
      induction of differentiation, mature human adipocytes were treated with 
      adipokines. Hsa-miR-26b was differentially expressed during human preadipocyte 
      differentiation. Tumor necrosis factor-alpha (TNF-alpha), leptin and resistin, but not 
      interleukin-6, caused downregulation of hsa-miR-26b expression in adipocytes. 
      These results suggest that the expression of hsa-miR-26b is affected by TNF-alpha, 
      leptin and resistin and that hsa-miR-26b may be an important mediator in 
      regulating the obesity-related insulin sensitivity and inflammatory responses.
FAU - Xu, Guangfeng
AU  - Xu G
AD  - Department of Laboratory Medicine, The 82nd Hospital of the People's Liberation 
      Army, No.100 Jiankang East Road, Huaian 223001, China.
FAU - Ji, Chenbo
AU  - Ji C
FAU - Shi, Chunmei
AU  - Shi C
FAU - Fu, Hailong
AU  - Fu H
FAU - Zhu, Lingling
AU  - Zhu L
FAU - Zhu, Lu
AU  - Zhu L
FAU - Xu, Lulian
AU  - Xu L
FAU - Chen, Ling
AU  - Chen L
FAU - Feng, Yueying
AU  - Feng Y
FAU - Zhao, Yaping
AU  - Zhao Y
FAU - Guo, Xirong
AU  - Guo X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121230
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Adipokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (MIRN26A microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (Resistin)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adipocytes/cytology/drug effects/metabolism
MH  - Adipokines/*pharmacology
MH  - Cells, Cultured
MH  - Gene Expression Regulation/drug effects
MH  - Humans
MH  - Interleukin-6/pharmacology
MH  - Leptin/pharmacology
MH  - MicroRNAs/*genetics
MH  - Obesity/genetics/metabolism
MH  - Resistin/pharmacology
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 2013/01/01 06:00
MHDA- 2013/09/14 06:00
CRDT- 2013/01/01 06:00
PHST- 2012/09/04 00:00 [received]
PHST- 2012/12/18 00:00 [accepted]
PHST- 2013/01/01 06:00 [entrez]
PHST- 2013/01/01 06:00 [pubmed]
PHST- 2013/09/14 06:00 [medline]
AID - 10.1007/s11033-012-2431-0 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2013 May;40(5):3577-82. doi: 10.1007/s11033-012-2431-0. Epub 2012 
      Dec 30.