PMID- 23276801
OWN - NLM
STAT- MEDLINE
DCOM- 20130624
LR  - 20220310
IS  - 1532-821X (Electronic)
IS  - 0003-9993 (Print)
IS  - 0003-9993 (Linking)
VI  - 94
IP  - 5
DP  - 2013 May
TI  - Weight-bearing versus nonweight-bearing exercise for persons with diabetes and 
      peripheral neuropathy: a randomized controlled trial.
PG  - 829-38
LID - S0003-9993(12)01284-1 [pii]
LID - 10.1016/j.apmr.2012.12.015 [doi]
AB  - OBJECTIVE: To determine the effects of weight-bearing (WB) versus 
      nonweight-bearing (NWB) exercise for persons with diabetes mellitus (DM) and 
      peripheral neuropathy (PN). DESIGN: Randomized controlled trial with evaluations 
      at baseline and after intervention. SETTING: University-based physical therapy 
      research clinic. PARTICIPANTS: Participants with DM and PN (N=29) (mean age +/- SD, 
      64.5+/-12.5y; mean body mass index [kg/m(2)] +/- SD, 35.5+/-7.3) were randomly assigned 
      to WB (n=15) and NWB (n=14) exercise groups. All participants (100%) completed 
      the intervention and follow-up evaluations. INTERVENTIONS: Group-specific 
      progressive balance, flexibility, strengthening, and aerobic exercise conducted 
      sitting or lying (NWB) or standing and walking (WB) occurred 3 times a week for 
      12 weeks. MAIN OUTCOME MEASURES: Measures included the 6-minute walk distance 
      (6MWD) and daily step counts. Secondary outcome measures represented domains 
      across the International Classification of Functioning, Disability and Health. 
      RESULTS: The WB group showed greater gains than the NWB group over time on the 
      6MWD and average daily step count (P<.05). The mean and 95% confidence intervals 
      (CIs) between-group difference over time was 29m (95% CI, 6-51) for the 6MWD and 
      1178 (95% CI, 150-2205) steps for the average daily step count. The NWB group 
      showed greater improvements than the WB group over time in hemoglobin A1c values 
      (P<.05). CONCLUSIONS: The results of this study indicate the ability of this 
      population with chronic disease to increase 6MWD and daily step count with a WB 
      exercise program compared with an NWB exercise program.
CI  - Copyright (c) 2013 American Congress of Rehabilitation Medicine. Published by 
      Elsevier Inc. All rights reserved.
FAU - Mueller, Michael J
AU  - Mueller MJ
AD  - Program in Physical Therapy and Department of Radiology, Washington University 
      School of Medicine, St Louis, MO, USA. muellerm@wustl.edu
FAU - Tuttle, Lori J
AU  - Tuttle LJ
FAU - Lemaster, Joseph W
AU  - Lemaster JW
FAU - Strube, Michael J
AU  - Strube MJ
FAU - McGill, Janet B
AU  - McGill JB
FAU - Hastings, Mary K
AU  - Hastings MK
FAU - Sinacore, David R
AU  - Sinacore DR
LA  - eng
GR  - R24HD650837/HD/NICHD NIH HHS/United States
GR  - R24 HD050837/HD/NICHD NIH HHS/United States
GR  - T32HD007434-17/HD/NICHD NIH HHS/United States
GR  - UL1 RR024992/RR/NCRR NIH HHS/United States
GR  - T32 HD007434/HD/NICHD NIH HHS/United States
GR  - 5 P60 DK20579/DK/NIDDK NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - P60 DK020579/DK/NIDDK NIH HHS/United States
GR  - R21 HD058938/HD/NICHD NIH HHS/United States
GR  - P30 DK020579/DK/NIDDK NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20121228
PL  - United States
TA  - Arch Phys Med Rehabil
JT  - Archives of physical medicine and rehabilitation
JID - 2985158R
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Diabetic Foot/*etiology/prevention & control
MH  - Diabetic Neuropathies/complications/physiopathology/*rehabilitation
MH  - Exercise Test
MH  - Female
MH  - Foot/physiopathology
MH  - Humans
MH  - Hypesthesia/etiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - *Mobility Limitation
MH  - *Resistance Training/adverse effects
MH  - Walking/*physiology
MH  - Weight-Bearing
PMC - PMC3637853
MID - NIHMS447744
COIS- No commercial party having a direct financial interest in the results of the 
      research supporting this article has or will confer a benefit on the authors or 
      on any organization with which the authors are associated.
EDAT- 2013/01/02 06:00
MHDA- 2013/06/26 06:00
PMCR- 2014/05/01
CRDT- 2013/01/02 06:00
PHST- 2012/08/07 00:00 [received]
PHST- 2012/11/19 00:00 [revised]
PHST- 2012/12/20 00:00 [accepted]
PHST- 2013/01/02 06:00 [entrez]
PHST- 2013/01/02 06:00 [pubmed]
PHST- 2013/06/26 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - S0003-9993(12)01284-1 [pii]
AID - 10.1016/j.apmr.2012.12.015 [doi]
PST - ppublish
SO  - Arch Phys Med Rehabil. 2013 May;94(5):829-38. doi: 10.1016/j.apmr.2012.12.015. 
      Epub 2012 Dec 28.