PMID- 23276953
OWN - NLM
STAT- MEDLINE
DCOM- 20130612
LR  - 20220224
IS  - 2768-6698 (Electronic)
IS  - 1093-9946 (Print)
IS  - 2768-6698 (Linking)
VI  - 18
IP  - 2
DP  - 2013 Jan 1
TI  - Homocysteine induces inflammatory transcriptional signaling in monocytes.
PG  - 685-95
AB  - Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular 
      disease. Here, we studied transcriptional regulation in homocysteine 
      (Hcy)-induced gene expression in monocytes (MC). We identified 11 Hcy-induced 
      genes, 17 anti-inflammatory cytokine interleukin 10-induced, 8 pro-inflammatory 
      cytokine interferon gamma (IFN gamma)-induced and 8 pro-inflammatory cytokine 
      tumor necrosis factor alpha (TNF alpha)-induced genes through literature search. 
      Binding frequency of 36 transcription factors (TFs) implicated in inflammation 
      and MC differentiation were analyzed within core promoter regions of identified 
      genes, and classified into 3 classes based on the significant binding frequency 
      to the promoter of Hcy-induced genes. Class 1 TFs exert high significant binding 
      frequency in Hcy-induced genes. Class 2 and 3 TFs have low and no significant 
      binding frequency, respectively. Class 1 TF binding occurrence in Hcy-induced 
      genes is similar to that in IFN gamma -induced genes, but not that in TNF alpha 
      -induced. We conclude that Hcy is a pro-inflammatory amino acid and induces 
      inflammatory transcriptional signal pathways mediated by class 1 TF. We term 
      class 1 TF as putative Hcy-responsive TFs.
FAU - Meng, Shu
AU  - Meng S
AD  - Department of Pharmacology, Temple University School of Medicine, 3500 North 
      Broad Street, 10th floor, Philadelphia, PA 19140, USA.
FAU - Ciment, Stephen
AU  - Ciment S
FAU - Jan, Michael
AU  - Jan M
FAU - Tran, Tran
AU  - Tran T
FAU - Pham, Hung
AU  - Pham H
FAU - Cueto, Ramon
AU  - Cueto R
FAU - Yang, Xiao-Feng
AU  - Yang XF
FAU - Wang, Hong
AU  - Wang H
LA  - eng
GR  - HL82774/HL/NHLBI NIH HHS/United States
GR  - R01 HL108910/HL/NHLBI NIH HHS/United States
GR  - R01 HL077288/HL/NHLBI NIH HHS/United States
GR  - HL108910/HL/NHLBI NIH HHS/United States
GR  - HL77288/HL/NHLBI NIH HHS/United States
GR  - R01 HL117654/HL/NHLBI NIH HHS/United States
GR  - HL67033/HL/NHLBI NIH HHS/United States
GR  - R01 HL110764/HL/NHLBI NIH HHS/United States
GR  - HL11076/HL/NHLBI NIH HHS/United States
GR  - R01 HL094451/HL/NHLBI NIH HHS/United States
GR  - HL94451/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130101
PL  - Singapore
TA  - Front Biosci (Landmark Ed)
JT  - Frontiers in bioscience (Landmark edition)
JID - 101612996
RN  - 0 (Cytokines)
RN  - 0 (Transcription Factors)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Cell Differentiation/drug effects
MH  - Cytokines/biosynthesis/*pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - Homocysteine/*pharmacology
MH  - Humans
MH  - Hyperhomocysteinemia/metabolism
MH  - Interferon-gamma/pharmacology
MH  - Interleukin-10/pharmacology
MH  - Monocytes/cytology/drug effects/*metabolism
MH  - Promoter Regions, Genetic/physiology
MH  - Signal Transduction/*drug effects
MH  - Transcription Factors/*metabolism
PMC - PMC3636574
MID - NIHMS449919
EDAT- 2013/01/02 06:00
MHDA- 2013/06/13 06:00
PMCR- 2013/04/26
CRDT- 2013/01/02 06:00
PHST- 2013/01/02 06:00 [entrez]
PHST- 2013/01/02 06:00 [pubmed]
PHST- 2013/06/13 06:00 [medline]
PHST- 2013/04/26 00:00 [pmc-release]
AID - 4131 [pii]
AID - 10.2741/4131 [doi]
PST - epublish
SO  - Front Biosci (Landmark Ed). 2013 Jan 1;18(2):685-95. doi: 10.2741/4131.